The Epstein–Barr virus (EBV) is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis ( “glandular fever”). It is also associated with particular forms of cancer, including Hodgkin’s lymphoma, Burkitt’s lymphoma, gastric cancer and nasopharyngeal carcinoma. About 200,000 cancer cases per year are thought to be attributable to EBV.
The Native Antigen Company have developed recombinant antigens that can be used for EBV research and assay development.
Epstein Barr Virus background
Epstein Barr Virus (EBV) is a double stranded DNA, enveloped virus that has a large genome encoding 200 proteins. Epstein Barr virus, also known as Herpes virus 4 (HHV4), belongs to the gammaherpesvirinae subgroup of the Herpesvirus family.
EBV is widely distributed and is estimated to affect around 90% of the human population. In developing countries, most children contract EBV infection at an early age. Whereas, in developed countries, primary EBV infection is more common in adolescents and adults. The Epstein-Barr virus is commonly spread from human-to-human through saliva and other body fluids (Centers for disease control and prevention).
In most cases, EBV Infection is asymptomatic but some individuals develop infectious mononucleosis, a condition that is generally self-limiting but can cause prolonged fatigue lasting for several months. After primary EBV infection, the virus remains latent and can re-activate under certain circumstances. In immunocompromised patients, EBV infection is associated with various malignancies, autoimmune disease and other chronic and acute illnesses.
Epstein-Barr virus primarily targets B-lymphocytes but is also reported to infect epithelial cells, T-cells, Natural killer cells, smooth muscle cells and monocytes (Hutt-Fletcher, L.M.).
Epstein Barr Antigens
Recombinant Epstein Barr Virus gp125 antigens have been developed and manufactured by The Native Antigen Company using our proprietary mammalian expression system, and are suitable for research and development into Epstein-Barr virus biology, and for immunoassay development
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