CMV specific antibodies

The Native Antigen Company Sheep anti-CMV pentamer antibody has been raised against recombinant CMV gH pentameric complex, expressed in mammalian cells.
The Cytomegalovirus gH pentamer complex is expressed on all wildtype hCMV strains but is notably missing from laboratory strains such as AD169 (Freed et al, 2013). This has placed severe limitations on vaccine development. Receptor-mediated viral entry into endothelial cells requires a functional gH pentameric complex, and this complex is one of the primary targets for antiviral antibodies in infected individuals.
The gH complex comprises the gH, gL, UL128, UL130 and UL131 proteins.
The sheep anti-CMV pentamer antibody has been shown to react with each of the components of the pentamer in Western blotting analysis.

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We hold good stocks of all our antigens to ensure a rapid delivery service worldwide. We like to be in touch with our customers so please drop us a line or give us a call on +44 (0)1865 595230. To place an order, please email order@thenativeantigencompany.com and for further information including price inquiries, bulk preparations and contract services email: contact@thenativeantigencompany.com.

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