Dengue Virus Antibodies

We offer a range of Dengue virus antibodies that have been validated using a panel of recombinant flavivirus proteins produced by The Native Antigen Company. This panel includes antibodies that bind all serotypes, as well as antibodies that are specific for each of the Dengue Virus serotypes.   All of these antibodies have been tested and shown not to cross-react with NS1 proteins from other flaviviruses.

Dengue virus (DENV) is a single-stranded RNA virus that belongs to the genus Flavivirus, which includes Zika virus, West Nile virus and Japanese Encephalitis virus. It causes dengue, an emerging disease that is a leading cause of illness and death in the tropics and subtropics. Reports suggest that more than one-third of the world’s population are living in areas at risk of DENV transmission (WHO). Dengue virus is transmitted to humans by mosquitoes, primarily Aedes aegypti species. Dengue infection is caused by any one of four related viruses DEN-1, DEN-2, DEN-3 and DEN-4, also referred to as serotypes, which co-circulate in endemic areas. Infection with one dengue serotype confers lifelong immunity but subsequent infection with other dengue serotypes is associated with an increased risk of developing severe dengue disease.

Early diagnosis of dengue and dengue serotypes is a vital step in patient management (WHO, 2009). However, many of the proteins expressed by Flaviruses are very similar, and serological testing for these viruses can be complicated by problems of cross-reactivity. The Native Antigen Company also supply a range of DENV antigens to support researchers working with Dengue virus serotypes.

References

  1. World Health Organization (WHO) – Dengue and severe dengue
  2. WHO – Guidelines for diagnosis, treatment, prevention and control (2009)

We hold good stocks of all our antigens to ensure a rapid delivery service worldwide. We like to be in touch with our customers so please drop us a line or give us a call on +44 (0)1865 595230. To place an order, please email order@thenativeantigencompany.com and for further information including price inquiries, bulk preparations and contract services email: contact@thenativeantigencompany.com.


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