HSV Specific antibodies

HSV specific antibodies, supplied by The Native Antigen Company, have been validated using our HSV virus lysates.

Human herpes simplex virus (HSV), also known as human herpes virus (HHV), is a large enveloped double stranded DNA virus that belongs to the Herpesviridae family, subfamily Alphaherpesvirinae. Human HSV exists as two distinct serotypes, herpes simplex virus type -1 (HSV-1) and type -2 (HSV-2). Both HSV-1 and HSV-2 are neurotrophic viruses that invade the central nervous system (CNS), where they replicate, and have the capacity to establish a latent infection (Nicoll, MP et al).

HSV-1 and HSV-2 are primarily transmitted from human-to-human through contact with mucosal surfaces and damaged skin, which are common sites of primary HSV infection. However, the route and site of infection differs for each serotype with some reported overlap. Typically, HSV-1 is transmitted through oral-to-oral contact giving rise to infection in the lips, eyes and oropharyngeal mucosa but HSV-1 infection can also occur in the genital tract through oral-genital contact. HSV-2 tends to be sexually transmitted via contact with infected mucosa or damaged skin associated with the genital tract.

HSV-1 establishes latency in the trigeminal ganglia, whereas HSV-2 tends to establish latency in the lumbar-sacral ganglia. Reactivation of either HSV-1 or HSV-2 can occur in immunosuppressed individuals or in seropositive individuals in response to a wide range of stimuli including periods of emotional and physical stress (WHO factsheet).

The Native Antigen Company supply HSV specific antibodies and highly purified viral antigens to support researchers working with human herpes virus.

References

  1. Nicoll, MP et al. (2012). The molecular basis of herpes simplex virus latency. FEMS Microbiol Rev.36(3): 684–705.
  2. World Health Organisation – Herpes Simplex Virus factsheet

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We hold good stocks of all our antigens to ensure a rapid delivery service worldwide. We like to be in touch with our customers so please drop us a line or give us a call on +44 (0)1865 595230. To place an order, please email order@thenativeantigencompany.com and for further information including price inquiries, bulk preparations and contract services email: contact@thenativeantigencompany.com.

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