JEV specific antibodies

The Japanese encephalitis virus (JEV) belongs to the genus Flavivirus, of the family Flaviviridae. JEV is also a member of the Japanese encephalitis serology complex, which also includes West Nile virus, St. Louis encephalitis and Murray Valley encephalitis virus.  In nature, JEV cycles primarily between water birds and mosquitoes, of the Culex species, but pigs can be infected and act as amplifying hosts. JEV can also be transmitted to incidental hosts including humans, horse and other mammals. In Asia, Japanese encephalitis (JE) is the leading cause of viral encephalitis in children, with up to 70,000 cases reported annually.

Diagnosis of JEV infection is achieved by serological testing for JEV specific IgM antibodies in the patient’s cerebrospinal fluid or serum. However, cross-reactivity of JEV specific antibodies with other Flaviviruses that co-circulate with JEV, such as Dengue virus, can be a challenge and can prevent accurate diagnosis (Johnson, BW).

The Native Antigen Company (NAC) also specialises in development and manufacture of native and recombinant viral antigens to support researchers working with JEV .

References

  1. Johnson, BW. et.al. (2016). Differential Diagnosis of Japanese Encephalitis Virus Infections with the Inbios JE Detect™ and DEN Detect™ MAC-ELISA Kits. Am. J. Trop. Med. Hyg. 94(4): 820–828.

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