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  • Staphylococcus aureus enterotoxin antibodies

Staphylococcus aureus enterotoxin antibodies

Staphylococcus aureus enterotoxin antibodies, supplied by The Native Antigen Company, recognise a range of enterotoxins produced by Staphylococcus aureus. Staphylococcus aureus enterotoxin antibodies are suitable for immunoassay research and development.

Staphylococcus aureus (S.aureus) is a gram-positive, non-spore forming bacterium that is a member of the genus Staphylococcus, which belongs to the family Staphylococcaceae. First recognised in 1880, S.aureus exists in many individuals as part of the normal microbiota, inhabiting the skin, nasal passages and respiratory tract. Pathogenic S.aureus secrete a range of potent toxins, which are a major cause of a wide range of pathogenic conditions in humans worldwide.
Enterotoxins, produced by S.aureus, are a major cause of food poisoning. Over 30 enterotoxins have been identified to date. Staphylococcus aureus enterotoxin B (SEB) and SEA are recognised as the most potent enterotoxin within the Staphylococcal family of toxin. SEB and SEA enterotoxin also acts as a potent bacterial superantigen, binding to and stimulating T lymphocytes and binding to major histocompatibility antigens (MHC), on antigen presenting cells of the immune system. Two separate domains on the 28kDa SEB protein are reported to be responsible for the two different functions of the toxin (Fries, B).
Staphylococcus aureus enterotoxins G and I have been associated with minor food poisoning outbreaks in Taiwan. Both toxins are heat stable and are transmitted to humans via contaminated foods including meat, meat products and unpasteurised dairy products. Both enterotoxin I and G have also been linked to cases of toxic shock syndrome, Staphylococcal scarlet fever and neonatal entropathy.
SEB and SEA are considered to be major causes of food borne infection causing food poisoning. The clinical symptoms of intoxication include fever, myalgia, vomiting, diarrhoea, headaches and in some cases shock. Currently there is no specific treatment for SEB or SEA mediated disease or shock. The condition is often self-limiting but support with hydration is often required. Currently, no licensed vaccine or antitoxin has been successfully developed (Ortega E).
Fries BC, Varshney AK. 2013. Bacterial Toxins-Staphylococcal Enterotoxin B. Microbiol Spectr. Dec;1(2)
Ortega E, Abriouel H, Lucas R, Gálvez A. 2010. Multiple roles of Staphylococcus aureus enterotoxins: pathogenicity, superantigenic activity, and correlation to antibiotic resistance. Toxins (Basel). Aug;2(8):2117-31.

We hold good stocks of all our antigens to ensure a rapid delivery service worldwide. We like to be in touch with our customers so please drop us a line or give us a call on +44 (0)1865 595230. To place an order, please email order@thenativeantigencompany.com and for further information including price inquiries, bulk preparations and contract services email: contact@thenativeantigencompany.com.

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