Oropouche virus

Oropouche virus (OROV) is an RNA virus that belongs to the family Bunyaviridae. Phylogenetic analysis of OROV has identified 4 virus genotypes (I, II, III, IV), which all occur in Brazil. In humans, OROV causes Oropouche fever, which is clinically characterized by a rapid-onset acute febrile illness. Oropouche fever is reported to be the second most common arboviral disease, next to Dengue fever, in the Brazilian Amazon region. Other symptoms associated with the disease are like those reported for Dengue, Zika, chikungunya, yellow fever and include headache, myalgia, joint pain, nausea and vomiting. In some cases, OROV can cause a type of viral meningitis.

In humans, OROV is transmitted by the biting midge culicoides paraensis, an insect vector that lives in urban areas and is widely distributed in South America. Since the virus was first isolated in 1955, OROV has caused 30 large scale epidemics in the Amazon region infecting at least 500,000 people. The incidence of Oropouche fever has now become widespread in Latin American countries where c.paraensis is present.

Given the geographical spread of OROV and the similarity of the symptoms of Oropouche fever to infections caused by Dengue, Zika, Chikungunya and Yellow Fever viruses, it is important to be able to differentiate diagnostically between these arboviral diseases.

The Native Antigen Company supply a highly purified recombinant OROV Nucleoprotein to support researchers and immunoassay developers working with Oropouche virus.

 

References:

  1. World Health Organization (WHO). Oropouche Virus disease – Peru. http://www.who.int/csr/don/03-june-2016-oropouche-peru/en/
  2. Vasconcelos, H.B. et al (2011). Molecular epidemiology of Oropouche virus, Brazil. Emerg Infect Dis. 17(5):800-6.

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