CCHF virus Oropouche virus Oropouche virus Gn protein Oropouche virus Gc

Oropouche Virus Gc protein – Mouse Fc

Product TypeRecombinant protein
Protein Conc.0.5 -1.0 mg/ml
Product CodeREC31603
Vial Size100ug | 500ug

From: $463.45

SKU: REC31603 Categories: ,

Product Description

Oropouche virus (OROV) is an RNA virus that belongs to the family Bunyaviridae.  The virus can cause an acute febrile illness, with other symptoms similar to those reported for Dengue, Zika, and Chikungunya virus infection,  including headache, myalgia, joint pain, nausea and vomiting. In some cases, OROV can cause a type of viral meningitis.

In humans, OROV is transmitted by the biting midge culicoides paraensis, an insect vector that lives in urban areas and is widely distributed in South America. Since the virus was first isolated in 1955, OROV has caused 30 large scale epidemics in the Amazon region infecting at least 500,000 people. The incidence of Oropouche fever has now become widespread in Latin American countries where c.paraensis is present.

Differential diagnosis of Oropouche virus infection from infection with Dengue, Zika or Chikungunya is recognised to be important, but there are few diagnostic assays available.    The Native Antigen Company provides a range of Oropouche virus antigens to facilitate research into the virus, and to support immunoassay develpment.

Oropouche virus Gc protein is a type I integral transmembrane protein, which is further modified by N-linked glycosylation.  Together with Gn protein it forms spikes on the virus particle and is essential for viral attachment and cell fusion. It has been described that for certain bunyaviruses, Gn and Gc are targeted by neutralizing antibodies

Oropouche virus Gc protein was expressed in mammalian HEK293 cells.  The transmembrane region of the protein has been replaced with mouse IgG Fc, via a glycine-serine linker.  The purified protein is approximately 140kD on analysis by reducing SDS-PAGE.


Tilston-Lunel, N.L. (2016)  J. Virol.  90:2616

  CofA REC31603-100 Batch 17080709

  SDS Oropouche Gc Mse Fc