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Mouse Anti SARS Coronavirus Membrane Antibody (2H2C4)

$447.95 excl. VAT

Mouse anti SARS-CoV Membrane antibody (2H2C4) is a monoclonal antibody that is specific for human coronavirus and reacts with the SARS-CoV membrane glycoprotein (also known as E1 or Matrix glycoprotein). Antibody is suitable for use in Western blot and ELISA.

Western blot: Detection of recombinant SARS-CoV membrane protein using MAB12394.

MOUSE ANTI SARS-COV MEMBRANE ANTIBODY (2H2C4)

Mouse anti SARS-CoV Membrane antibody (2H2C4) is a monoclonal antibody that is specific for human coronavirus and reacts with the SARS-CoV membrane glycoprotein (also known as E1 or Matrix glycoprotein). Antibody is suitable for use in Western blot and ELISA.

 

PRODUCT DETAILS – MOUSE ANTI SARS-COV MEMBRANE ANTIBODY

  • Mouse anti SARS-CoV Membrane antibody (2H2C4).
  • Immunogen was recombinant fragment of SARS-CoV membrane glycoprotein expressed in E. coli.
  • Produced from tissue culture supernatant.
  • Suitable for use in Western blot and ELISA.

 

BACKGROUND

SARS (severe acute respiratory syndrome) is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness, such as the common cold, in humans. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The complete sequence of the SARS coronavirus contains 25 open reading frames.

SARS-m is a membrane (M) protein which plays a key part in virion assembly. As a component of the viral envelope it plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. It interacts with the nucleocapsid and S proteins and one of its functions is to mediate the incorporation of the spikes into the viral envelope (Opstelten et al., 1995; Narayanan et al., 2000). Membrane proteins are capable of self-assembly and release in the form of membrane-enveloped vesicles, and of forming virus-like particles (VLPs) when co-expressed with SARS-CoV nucleocapsid (N) protein (Tseng et al., 2013).

 

REFERENCES

  • Narayanan et al. (2000). Characterization of the coronavirus M protein and nucleocapsid interaction in infected cells. J Virol. 2000 Sep; 74(17):8127-34.
  • Opstelten et al. (1995). Envelope glycoprotein interactions in coronavirus assembly. J Cell Biol. 1995 Oct; 131(2):339-49.
  • Tseng et al. (2013). Identifying SARS-CoV Membrane Protein Amino Acid Residues Linked to Virus-Like Particle Assembly. PLoS One. 8(5): e64013.

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