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Tick-Borne Encephalitis

Tick-borne encephalitis virus (TBEV) causes 13,000 cases of human meningitis and encephalitis annually. Mortality varies depending on the sub-type, but long-term neuropsychiatric disorders can occur in a significant proportion of patients.

 

We offer recombinant TBEV NS1 proteins developed within our proprietary mammalian expression system.

TBEV background

Tick-borne encephalitis virus (TBEV) belongs to the genus Flavivirus, of the family Flaviviridae. The virus is primarily transmitted through the bite of infected hard ticks, of the family Ixodidae. Small rodents are the primary hosts for Tick-borne encephalitis virus with humans acting as accidental hosts. The virus can also be transmitted to humans through unpasteurized milk in areas where TBEV is prevalent (Centers for disease control and prevention).

TBEV is a neurotrophic virus that causes tick-born encephalitis (TBE) in humans, affecting the central nervous system (CNS). TBE is endemic in many parts of Europe, China, Mongolia and the Russian Federation and is the most common tick-born CNS infection in these areas (World health organization). Three subtypes of TBEV have been recognised that cause tick-borne encephalitis, which are European, Far-Eastern and Siberian.

TBEV infection is asymptomatic in most cases with some individuals presenting with influenza-like symptoms. In symptomatic cases, TBEV infection typically presents as meningitis, encephalitis or meningoencephalitis. A high percentage of acute TBE cases may also develop post-encephalitic syndrome with long-lasting neuropsychiatric symptoms or neurological dysfunction (Bogovic, P).

Diagnosis of TBE infection is primarily based on clinical presentation and serological testing for TBEV specific IgM and IgG antibodies in the patient’s serum and cerebrospinal fluid. There is no anti-viral treatment for TBEV. However, several effective vaccines for TBEV are currently available which are based on European and Far-Eastern strains of the virus (World health organization).

Tick-Borne Encephalitis Antigens

The Native Antigen Company prepare recombinant TBEV NS1 protein in a proprietary mammalian cell expression system, which generates highly pure NS1 protein in glycosylated form and predominantly in hexameric format.

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