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Trichomoniasis

Trichomoniasis is a sexually transmitted infection (STI) caused by a tiny parasite called Trichomonas vaginalis (TV). There are an estimated 5 million new cases in the US each year.

We prepare antigenic preparations of Trichomonas in cell culture for use in immunoassay development.

Trichomonas background

Trichomonas vaginalis (Tv) is a flagellated parasitic protozoan which belongs to the Trichomonadidae family of parasites. Trichomonas vaginalis is the causative agent of the sexually transmitted disease known as Trichomoniasis. Morphologically, Tv exists as a trophozoite and cannot survive for long periods in the external environment. It is an obligate parasite that infects both men and women. The parasite infects the squamous epithelium of the genital tract, and replicates in the lower genital tract of women and the urethra and prostate of men (Kissinger, P).

In humans, Tv is transmitted through skin-to skin contact usually during sexual activity. Tv infection is reported to be the most common, non-viral, sexually transmitted infection (STI) in the world. The prevalence of Tv infection varies from country to country but >11 % of women are thought to be affected worldwide. However, the Tv is not a reportable disease and therefore the incidence of Tv infection may be higher. Studies also suggest that Tv infection is associated with an increased risk of developing other STIs including human immunodeficiency virus (HIV).

In both women and men, Tv is asymptomatic in most cases. However, a third of asymptomatic cases in women can become symptomatic over a period of 6 months. Symptoms of Tv infection include vaginal discharge, dysuria, itching, vulvar discharge and abdominal pain. Tv infection has also been associated with pelvic inflammatory disease, low birth rate and preterm delivery. In men, Tv infection can cause epididymitis, prostatitis and decreased sperm motility (CDC).

Improvements in diagnostic testing for Tv may reveal a higher incidence of Tv infection, which given the association with an increased risk of developing other STIs, is a significant cause for concern in the global health community.

References

Kissinger P. 2015. Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues.BMC Infect Dis. Aug 5;15:307.

Centers for Disease Control and Prevention: Trichomoniasis

Trichomonas Antigens

Washed and lysed purified Trichomonas vaginalis protozoa are prepared in carefully controlled conditions, being suitable for use in IVD kit manufacture or research.

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