Yellow Fever virus (YFV) Envelope DIII domain, Recombinant

Recombinant Yellow Fever virus (YFV) DIII domain of the Envelope protein. The protein was produced in E. Coli and purified from cell pellet by immobilized metal affinity and ion exchange chromatography.

Yellow Fever virus (YFV) Envelope DIII domain, Recombinant

• Accession: AAB30044.2
• Strain/Isolate: RJ-2906
• Tag: His-Tag, C-Terminus
• Expressed in E.coli
• Presented as liquid in 20 mM potassium carbonate, pH 9.6

BACKGROUND

Yellow fever virus (YFV) is a mosquito‑borne flavivirus that can cause severe hemorrhagic disease and jaundice in humans and remains a major public health concern in parts of Africa and South America (WHO, 2025; Gianchecchi et al., 2022). The viral envelope (E) glycoprotein of YFV, as in other flaviviruses, is the key surface protein mediating receptor binding and membrane fusion and is organized into three distinct domains, including Domain III (DIII), which forms part of the external surface of the virion (Modis et al., 2017; Davis et al., 2022). For Yellow Fever virus strain RJ‑2906, the Envelope DIII domain can be produced in recombinant form and used as a defined antigenic component in experimental studies, allowing dissection of strain‑ and domain‑specific properties in the context of YFV envelope function and immune recognition (Stock et al., 2013; Furtado et al., 2022).

REFERENCES

• Davis, E. H., et al. (2022). Impact of yellow fever virus envelope protein on wild-type and 17D vaccine strain phenotypes. npj Vaccines.
• Furtado, N. D., et al. (2022). Biological Characterization of Yellow Fever Viruses from Brazil. Frontiers in Microbiology.
• Gianchecchi, E., et al. (2022). Yellow Fever: Origin, Epidemiology, Preventive Strategies and Future Directions. Pathogens.
• Modis, Y., et al. (2017). Structures & Functions of Flavivirus Envelope Glycoprotein. Current Opinion in Virology.
• Stock, N. K., et al. (2013). Biological and Phylogenetic Characteristics of Yellow Fever Virus Strains. Journal of Virology.