+44 (0)1865 595230
0 Items

Ebola

Ebola virus causes a viral haemorrhagic fever in humans and other primates. The disease has a high mortality rate, killing between 25-90% of those infected, with an average mortality rate of 50%. Since a significant outbreak in West Africa, in 2014/15, there have been further sporadic outbreaks, leading to continued concern about re-emergence.

The Native Antigen Company offer a range of recombinant Ebola proteins and antibodies to support research into this disease.

Ebola Background

Ebola virus disease (EVD) is a severe illness caused by several species of Ebolavirus (EBOV), of the family Filoviridae. Prior to 2007, four species of EBOV had been identified, with two (Zaire ebolavirus and Sudan ebolavirus) having caused large outbreaks in humans. The presence of a fifth EBOV species, Bundibugyo ebolavirus (BEBOV) was identified after an outbreak of EVD in the Bundibugyo district of western Uganda in 2007. Outbreaks of EVD are associated with person-to-person transmission after the virus is introduced to human populations from its zoonotic reservoir. During outbreaks, the virus is commonly transmitted through direct contact with infected persons or their bodily fluids. The onset of EVD is associated with nonspecific clinical symptoms, including fever, myalgia, headache, abdominal pain, nausea, vomiting, and diarrhoea. In the later stages of disease, overt haemorrhage has been reported in up to 50% of cases.

The Zaire subtype of the EBOV family is currently the most significant in relation to outbreaks of disease in humans. This subtype was responsible for the largest ever outbreak of EVD, which started in West Africa in 2014 and was finally declared over only in early 2016.

References

  1. Adam MacNeil et al (2010). Proportion of Deaths and Clinical Features in Bundibugyo Ebola Virus Infection, Uganda. Emerg Infect Dis. 16(12): 1969–1972.

Ebola Antigens

The Native Antigen Company supply highly purified viral antigens, developed using our proprietary mammalian expression system to support researchers working with EBOV. Our range includes envelope glycoproteins from both Zaire and Bundibugyo strains and Ebola VLPs, which contain nucleoprotein, glycoprotein and VP40 antigens.

Ebola Antibodies

To complement our range of Ebola virus antigens. we are pleased to offer a range of monoclonal and polyclonal antibodies, specific to Ebola virus proteins. These include antibodies that are specific to Ebola nucleoprotein and VP40 antigens.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Challenges to Effective Yellow Fever Diagnostics

Yellow fever is a haemorrhagic viral disease, transmitted by infected mosquitos in Africa and South America. While an effective vaccine is available, inadequate vaccination of endemic areas has made diagnostics a necessity to controlling ongoing outbreaks. However,...

Five Methods You Can Use to Overcome Zika-Dengue Cross-Reactivity

Cross-reactivity between the Zika and Dengue viruses in serological assays is one of the biggest challenges faced by the epidemiologists, academics and pharmaceutical companies trying to control the Zika epidemic, as it brings the quality and reliability of diagnostic...

Why Zika virus’s cross-reactivity with Dengue might be hampering your research

Given the impact of Zika, it’s no surprise that a global contingent of epidemiologists, academic researchers, and pharmaceutical companies are striving to develop effective disease control measures and treatments. One challenge currently hindering the...

How The Native Antigen Company responds to the WHO list of priority infectious diseases

In 2015, a broad group of public health and science experts gathered in Geneva to discuss emerging infectious diseases that are likely to cause future severe epidemics and public health emergencies. Organised by the World Health Organization (WHO), their aim was to...

Native Antigen release a panel of serotype specific monoclonal antibodies

  There are four distinct serotypes of Dengue Virus circulating around the world, causing Dengue fever infection which is the most important worldwide arboviral disease. There are nearly 400 million cases of Dengue annually, and around 25% present with so called...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

10 + 7 =

Live Customer Feedback