0 Items
Select Page

Ebola

Ebola virus causes a viral haemorrhagic fever in humans and other primates. The disease has a high mortality rate, killing between 25-90% of those infected, with an average mortality rate of 50%. Since a significant outbreak in West Africa, in 2014/15, there have been further sporadic outbreaks, leading to continued concern about re-emergence.

The Native Antigen Company offer a range of recombinant Ebola proteins and antibodies to support research into this disease.

Ebola Background

Ebola virus disease (EVD) is a severe illness caused by several species of Ebolavirus (EBOV), of the family Filoviridae. Prior to 2007, four species of EBOV had been identified, with two (Zaire ebolavirus and Sudan ebolavirus) having caused large outbreaks in humans. The presence of a fifth EBOV species, Bundibugyo ebolavirus (BDBV) was identified after an outbreak of EVD in the Bundibugyo district of western Uganda in 2007. Outbreaks of EVD are associated with person-to-person transmission after the virus is introduced to human populations from its zoonotic reservoir. During outbreaks, the virus is commonly transmitted through direct contact with infected persons or their bodily fluids. The onset of EVD is associated with nonspecific clinical symptoms, including fever, myalgia, headache, abdominal pain, nausea, vomiting, and diarrhoea. In the later stages of disease, overt haemorrhage has been reported in up to 50% of cases.

The Zaire subtype of the EBOV family is currently the most significant in relation to outbreaks of disease in humans. This subtype was responsible for the largest ever outbreak of EVD, which started in West Africa in 2014 and was finally declared over only in early 2016.

References

  1. Adam MacNeil et al (2010). Proportion of Deaths and Clinical Features in Bundibugyo Ebola Virus Infection, Uganda. Emerg Infect Dis. 16(12): 1969–1972.

Ebola Antigens

The Native Antigen Company supply highly purified viral antigens, developed using our proprietary mammalian expression system to support researchers working with EBOV. Our range includes envelope glycoproteins from both Zaire and Bundibugyo strains and Ebola VLPs, which contain nucleoprotein, glycoprotein and VP40 antigens.

Ebola Antibodies

To complement our range of Ebola virus antigens. we are pleased to offer a range of monoclonal and polyclonal antibodies, specific to Ebola virus proteins. These include antibodies that are specific to Ebola nucleoprotein and VP40 antigens.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

A Q&A with David Flavell of Leukaemia Busters

In this blog, we speak with Dr. David Flavell about his scientific career, the legacy of Leukaemia Busters, and the recent impact that COVID-19 has had on his research.Tell me about your scientific background David. I was born in a seaside town called Southport in...

Avoiding the Immunopathology Pitfalls of a COVID-19 Vaccine

In the second of a three-part series on COVID-19 vaccines, we explore the potential challenges in stimulating safe vaccine responses and outline the role that diagnostics will play in guiding their development.Rogue Responses Antibodies play a crucial role in...

The Bumpy Road to a Cytomegalovirus Vaccine

The development of a cytomegalovirus vaccine has been 50 years in the making. Are there any technologies in the pipeline that could prompt a breakthrough? This article was originally posted online at The Medicine Maker, a Texere publication.To say that...

Why We Need Antigen and Antibody Tests for COVID-19

RT-PCR is the workhorse of viral diagnosis and has been invaluable in COVID-19 case confirmation and isolation guidance. However, while fast and sensitive, PCR suffers from some inherent drawbacks that limit it to diagnosis during the acute phase of infection. To...

Gonorrhea: What’s Currently in the Clinical Pipeline?

This article was written by our friends at Infectious Diseases Hub, a free-to-access website that aims to deliver up-to-date, essential research and information on all aspects of microbiology, virology, mycology and parasitology – from bench to bedside....

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

4 + 1 =

Live Customer Feedback

Join our mailing list

* indicates required