0 Items
Select Page

Cytomegalovirus

Cytomegalovirus (CMV) is a ubiquitous virus that can infect almost anyone. Most people are unaware that they have CMV, because it rarely causes problems in healthy people. But for pregnant women or those with weakened immune system, CMV is cause for concern. A woman who develops an active CMV infection during pregnancy may pass the virus to her baby, which in a small percentage of cases can cause congenital birth defects. For people with compromised immunity, especially due to organ transplantation, CMV infection can be fatal.

At The Native Antigen Company, we offer an extensive range of reagents for CMV research. These include preparations of native purified virus, mammalian-expressed recombinant proteins and a panel of related antibodies.

Cytomegalovirus Background

Cytomegalovirus (CMV, or human betaherpesvirus 5) is a human-specific double-stranded DNA virus, belonging to the Herpesviridae family. CMV is ubiquitous and CMV infection is globally widespread. The virus is transmitted through direct contact with infected bodily fluids, or though contact with virus-infected transplant and transfusion material. CMV can also be transferred in utero from mother to foetus during pregnancy resulting in congenital CMV (cCMV) infection of new-borns. In healthy adults and children, CMV infection is self-limiting with most cases being asymptomatic or presenting with mild, non-specific flu-like or mononucleosis-like symptoms. However, CMV can cause clinical disease in all organs of immunocompromised patients and congenital complications in babies born to infected mothers. Congenital CMV infection represents a significant health risk to new-borns, as children with CMV infection may experience physical disability, learning difficulties, visual impairment and deafness. Currently, there is no licensed vaccine to prevent CMV infection. Therefore, attempts to reduce the risk of cCMV infection by improving awareness, behaviour, screening, diagnosis and the treatment of symptomatic cases are the most immediate means of mitigating the health burden caused by cCMV (CDC).

References

  1. Centers for Disease Control and Prevention: Cytomegalovirus (CMV) and congenital CMV infection.

Cytomegalovirus Antigens

The Native Antigen Company have developed a range of CMV antigens that are suitable for both IVD assay development and vaccine R&D studies. These antigens include preparations from native virus and highly purified recombinant proteins, expressed in mammalian cells.

Our recombinant antigens include the two key vaccine candidates for CMV: CMV pentamer protein and glycoprotein B.

Cytomegalovirus Antibodies

Our CMV-specific antibodies have been fully validated using antigens produced by The Native Antigen Company. The range includes CMV-specific antibodies against glycoprotein B and CMV pentamer. Sheep anti-CMV pentamer antibody has been raised against recombinant CMV gH pentameric complex, expressed in mammalian cells, and has been shown to react with each of the components of the pentamer in Western blotting analysis. Mouse anti-CMV glycoprotein B antibody clone HCMV37, recognises and binds a neutralising epitope on CMV glycoprotein B. It has been tested on recombinant CMV glycoprotein B, produced by the Native Antigen Company and has shown to bind effectively in direct ELISA.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

From Outbreak to Epidemic: A Short History of The Ebola Virus

In the first of a two-part series, we discuss the history of the Ebola virus up to the ongoing outbreak in the Democratic Republic of Congo, and why this disease has been so challenging to fight. The 2014/15 epidemic In the summer of 2014, the world watched as the...

ELISA Formats for Infectious Disease Diagnostics

The field of diagnostics is rapidly developing, yet ELISA and PCR methods remain the most commonly used techniques in the diagnosis of bacterial and viral infections. In this blog, we discuss the advantages of using serological methods over molecular, PCR-based...

The world’s most extensive range of NS1-specific antibodies for flavivirus research

The Native Antigen Company first gained prominence in 2016, when it developed highly pure Zika virus NS1 protein during the 2015/2016 epidemic. Since then, the company has developed an extensive range of highly specific antigens, antibodies and immunoassays for...

Flavivirus NS1: A Short Introduction

In the first of a two-part series, we describe the structure of Flavivirus Non-Structural Protein 1 (NS1) and the role that it plays in viral pathogenesis. Flavivirus proteins Flaviviruses are single-stranded, enveloped RNA viruses, belonging to the Flaviviridae...

Paper Synopsis: ELISA formats and antibody quenching to reduce ZIKV cross-reactivity

While the 2015/16 Zika epidemic no longer makes the headlines, there remains a crucial need to accurately and reliably diagnose Zika virus (ZIKV) infection to identify and manage further outbreaks. However, high levels of cross-reactivity among cocirculating...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

7 + 12 =

Live Customer Feedback