0 Items
Select Page

Toxoplasma gondii

Toxoplasma gondii (T. gondii) causes the parasitic disease Toxoplasmosis. It is a widespread disease that primarily affects members of the cat family but can be transmitted to humans through infected meat and cat faeces. Most humans infected with T.gondii remain asymptomatic or develop mild flu-like symptoms but severe clinical disease can occur in immunocompromised patients. In addition, T. gondii infection in pregnant women can cause congenital defects in the newborn or may lead to spontaneous abortion.

The Native Antigen Company offer high quality reagents for T.gondii research and immunoassay development.

Toxoplasma gondii Background

Toxoplasma gondii (T. gondii) is an obligate intracellular parasitic protozoan of the phylum Apicomplexa. It is the causative agent of the disease Toxoplasmosis, a common parasitic zoonoses which is widespread throughout most of the world. The domestic cat and other members of the family Felidae are the only definitive hosts for T.gondii. However, T.gondii is also capable of infecting a wide range of birds and mammals, including humans, which act as intermediate hosts.

In domestic cats, sexual replication of T.gondii occurs with the release of oocysts, in cat faeces, into the environment. In humans, T.gondii is primarily acquired by ingesting undercooked meat contaminated with bradyzoites (tissue cysts), drinking water contaminated by oocysts, or via accidental ingestion of cat faeces containing oocysts. In pregnant women, infected with T.gondii, vertical transmission of the parasite can occur causing congenital defects or miscarriage. In addition, infection via blood transfusion and organ transplant can also occur in rare cases (CDC).

In humans, ingestion of T.gondii tissue cysts or oocysts causes rupture of the cyst wall releasing sporozoites, which invade enterocytes in the small intestine and start to replicate. Infected cells then release tachyzoites which can enter adjacent cells and continue to multiply. This process of cell invasion and intracellular replication can continue allowing tachyzoites to disseminate throughout the body affecting multiple organs. After initial infection, tachyzoites form bradyzoites in human nerve and muscle tissue where T.gondii can remain dormant during the life of the host (Black, MW).

Most humans infected with T.gondii remain asymptomatic, or may present with mild flu-like symptoms including fever, headache, muscle pain and lymphadenopathy. However, in immunocompromised individuals, Toxoplasmosis can cause clinical disease including retinochoroiditis, myocarditis and meningoencephalitis, potentially leading to death. In pregnant women, T.gondii infection during the early stages of pregnancy can result in a miscarriage, a stillborn baby or congenital defects of the newborn including visual defects and mental disability (CDC).

Diagnosis of T.gondii infection is currently perfomed using serological techniques and indirect immunofluorescence to detect Toxoplasma specific antibodies.

References

Centers for Disease Control and Prevention: Parasites – Toxoplasmosis (Toxoplasma infection)

Black MW, Boothroyd JC. 2000. Lytic cycle of Toxoplasma gondii. Microbiol Mol Biol Rev. Sep;64(3):607-23.

Toxoplasma gondii Antibodies

We offer a monoclonal antibody specific to T. gondii, suitable for the development of ELISA and other immunoassays.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Viral Lysates for Diagnostic Research

We've recently expanded our range of native viral cell lysates to complement our highly pure recombinant antigens. Here, we explain how our lysates are made and their uses in infectious disease R&D.What are viral lysates? Put simply, viral lysates are extracts of...

Cellular Receptors for Viral Entry

The most crucial step for viruses during human infection is recognition and entry into host cells. For this to happen, specific proteins on the virus capsid interact with those on the host cells' surface, through a 'lock-and-key'-type mechanism that mediates...

Using Adenoviruses to Fight Cancer

In the second of a 2-part series, we discuss how adenoviruses are being developed to treat cancer and some of the hurdles these platforms face from our own immune systems. Curing cancer is one of the biggest challenges of the 21st century. Our knowledge of cancer’s...

New Immunofluorescence Data for our CMV, Yellow Fever and Ebola Antibodies

In September 2018 The Native Antigen Company and Virology Research Services (VRS) were awarded the Medical Research Council (Proximity to Discovery Award for Knowledge Exchange) to test a large panel of our viral antibodies in immunofluorescence applications. This...

Why are ticks such good vectors of pathogens?

In this blog, Professor Patricia Nuttall discusses what makes ticks such effective vectors of pathogens and how we might prevent the spread of tick-borne diseases. About Patrica Nuttall Pat Nuttall is Emeritus Professor of Arbovirology in the Department of Zoology,...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

9 + 15 =

Live Customer Feedback