0 Items
Select Page

Toxoplasma gondii

Toxoplasma gondii (T. gondii) causes the parasitic disease Toxoplasmosis. It is a widespread disease that primarily affects members of the cat family but can be transmitted to humans through infected meat and cat faeces. Most humans infected with T.gondii remain asymptomatic or develop mild flu-like symptoms but severe clinical disease can occur in immunocompromised patients. In addition, T. gondii infection in pregnant women can cause congenital defects in the newborn or may lead to spontaneous abortion.

The Native Antigen Company offer high quality reagents for T.gondii research and immunoassay development.

Toxoplasma gondii Background

Toxoplasma gondii (T. gondii) is an obligate intracellular parasitic protozoan of the phylum Apicomplexa. It is the causative agent of the disease Toxoplasmosis, a common parasitic zoonoses which is widespread throughout most of the world. The domestic cat and other members of the family Felidae are the only definitive hosts for T.gondii. However, T.gondii is also capable of infecting a wide range of birds and mammals, including humans, which act as intermediate hosts.

In domestic cats, sexual replication of T.gondii occurs with the release of oocysts, in cat faeces, into the environment. In humans, T.gondii is primarily acquired by ingesting undercooked meat contaminated with bradyzoites (tissue cysts), drinking water contaminated by oocysts, or via accidental ingestion of cat faeces containing oocysts. In pregnant women, infected with T.gondii, vertical transmission of the parasite can occur causing congenital defects or miscarriage. In addition, infection via blood transfusion and organ transplant can also occur in rare cases (CDC).

In humans, ingestion of T.gondii tissue cysts or oocysts causes rupture of the cyst wall releasing sporozoites, which invade enterocytes in the small intestine and start to replicate. Infected cells then release tachyzoites which can enter adjacent cells and continue to multiply. This process of cell invasion and intracellular replication can continue allowing tachyzoites to disseminate throughout the body affecting multiple organs. After initial infection, tachyzoites form bradyzoites in human nerve and muscle tissue where T.gondii can remain dormant during the life of the host (Black, MW).

Most humans infected with T.gondii remain asymptomatic, or may present with mild flu-like symptoms including fever, headache, muscle pain and lymphadenopathy. However, in immunocompromised individuals, Toxoplasmosis can cause clinical disease including retinochoroiditis, myocarditis and meningoencephalitis, potentially leading to death. In pregnant women, T.gondii infection during the early stages of pregnancy can result in a miscarriage, a stillborn baby or congenital defects of the newborn including visual defects and mental disability (CDC).

Diagnosis of T.gondii infection is currently perfomed using serological techniques and indirect immunofluorescence to detect Toxoplasma specific antibodies.

References

Centers for Disease Control and Prevention: Parasites – Toxoplasmosis (Toxoplasma infection)

Black MW, Boothroyd JC. 2000. Lytic cycle of Toxoplasma gondii. Microbiol Mol Biol Rev. Sep;64(3):607-23.

Toxoplasma gondii Antibodies

We offer a monoclonal antibody specific to T. gondii, suitable for the development of ELISA and other immunoassays.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

The Immune Evasion Strategies of Lassa Fever Virus

In this blog, we outline the molecular pathogenesis of Lassa viral haemorrhagic fever and introduce our extended range of Lassa Fever virus antigens and antibodies.Viral haemorrhagic fevers Viral haemorrhagic fevers (VHF) are a diverse group of viral illnesses that...

Diphtheria toxin: The nuts and bolts

The Native Antigen Company manufactures high-quality Diphtheria toxin in its native format for a range of applications and is offering a 30% discount on this product for the remainder of 2019. In this blog we explain the structure, mechanism-of-action and applications...

Diagnosing HIV in resource-limited settings

In this blog, we discuss the need for improved point-of-care (PoC) diagnostics for HIV and present the virus's cellular mechanism to illustrate our new range of HIV antigens and antibodies. HIV in the developed world On June 5th 1981 in Los Angeles, California, 5...

Our Product Pipeline

If you’ve been following us on social media recently, you might have noticed that we’ve been releasing a lot of new antigens and antibodies. In this blog, we explain how we use the WHO R&D Blueprint to guide our product development and present some highlights from...

From Outbreak to Epidemic: A Short History of The Ebola Virus

In the first of a two-part series, we discuss the history of the Ebola virus up to the ongoing outbreak in the Democratic Republic of Congo, and why this disease has been so challenging to fight. The 2014/15 epidemic In the summer of 2014, the world watched as the...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

6 + 12 =

Live Customer Feedback

Join our mailing list

* indicates required