0 Items
Select Page

Mumps Virus

Mumps is a highly contagious disease caused by the mumps virus (MuV). The virus primarily affects children causing a self-limiting febrile illness with inflammation of the salivary glands. Infection in adults can lead to clinical complications including orchitis in men. Since the 1960’s, the introduction of an effective vaccine and a widespread vaccination program has significantly reduced cases of mumps. However, recent outbreaks of mumps in vaccinated individuals have been reported causing concern in the global health community.

Mumps Virus Background

Mumps virus (MuV) is a single stranded negative-sense RNA virus, which belongs to the Rubulavirus genus of the family Paramyxoviridae. The viral genome is contained within a nucleocapsid enclosed by a lipid envelope that consists of three layers. The outer layer contains glycoproteins which have neuraminidase, haemmaglutinin and cell-fusion (F-protein) activities. One serotype and 13 genotypes of MuV have been identified to date.

Mumps, also known as infectious parotitis, is a highly contagious disease caused by the mumps virus.  MuV is globally widespread and predominantly affects children but can also cause disease in adults. Humans are the only known host of mumps virus and infection is spread from person-to-person via respiratory aerosol droplets, saliva and direct contact with infected individuals (WHO).

Mumps infection is typically a mild self-limiting disease, which resolves within 2-3 weeks of symptom onset. The disease is asymptomatic in a third of cases, but individuals can still be contagious. When symptoms of MuV infection occur they include headache, fever and general malaise followed by inflammation and swelling of the parotid glands. The MuV can also cause inflammation in other organs including the testes causing orchitis, which may lead to testicular atrophy in males post puberty. The virus is also highly neutrophic and may cause complications in some cases of MuV infection, such as aseptic meningitis, viral encephalitis and transient deafness (Rubin, S).

Since the introduction of an effective vaccine in the 1960’s, global cases of Mumps have been in decline. However, outbreaks of MuV in vaccinated individuals and complications associated with some vaccine strains have been reported in recent years. These cases have been a cause for concern and have renewed interest in the mumps virus.

References

Mumps Virus Antigens

We are pleased to offer a recombinant Mumps virus lysate for research use. This lysate can be used as an antigen, for the purification of viral proteins, or in assays for the detection of viral antibodies.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Viral Lysates for Diagnostic Research

We've recently expanded our range of native viral cell lysates to complement our highly pure recombinant antigens. Here, we explain how our lysates are made and their uses in infectious disease R&D.What are viral lysates? Put simply, viral lysates are extracts of...

Cellular Receptors for Viral Entry

The most crucial step for viruses during human infection is recognition and entry into host cells. For this to happen, specific proteins on the virus capsid interact with those on the host cells' surface, through a 'lock-and-key'-type mechanism that mediates...

Using Adenoviruses to Fight Cancer

In the second of a 2-part series, we discuss how adenoviruses are being developed to treat cancer and some of the hurdles these platforms face from our own immune systems. Curing cancer is one of the biggest challenges of the 21st century. Our knowledge of cancer’s...

New Immunofluorescence Data for our CMV, Yellow Fever and Ebola Antibodies

In September 2018 The Native Antigen Company and Virology Research Services (VRS) were awarded the Medical Research Council (Proximity to Discovery Award for Knowledge Exchange) to test a large panel of our viral antibodies in immunofluorescence applications. This...

Why are ticks such good vectors of pathogens?

In this blog, Professor Patricia Nuttall discusses what makes ticks such effective vectors of pathogens and how we might prevent the spread of tick-borne diseases. About Patrica Nuttall Pat Nuttall is Emeritus Professor of Arbovirology in the Department of Zoology,...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

1 + 15 =

Live Customer Feedback