0 Items
Select Page

Chikungunya Virus

Chikungunya virus is an Alphavirus that has recently been the cause of large-scale outbreaks in the Americas since 2013. Clinical symptoms including high fever, rash, headache, vomiting, myalgia, and severe joint pain, which can last for many years. CHIKV fever is a debilitating illness that has a significant economic impact in areas where CHIKV is endemic.

At The Native Antigen Company, we offer an extensive range of Chikungunya antigens and antibodies to support IVD assay development and vaccine R&D. These include mammalian expressed recombinant virus-like particles, soluble envelope proteins, cell receptor proteins and neutralising monoclonal antibodies. We also offer ELISA assays for the detection of IgG and IgM antibody response to Chikungunya virus.

Chikungunya Virus Background

Chikungunya virus (CHIKV) is a positive sense, single-stranded RNA virus that belongs to the genus Alphavirus, a member of the Togaviridae family of viruses. CHIKV is closely related to other alphaviruses including Ross River virus, O’nyong’nyong virus and Mayaro virus, which are know to cause arthritis. Three genotypes of Chikungunya virus have been identified to date and named Asian, East Central South African and West African, according to their geographical distribution.

In urban areas, humans act as the major host for CHIKV and the virus is primarily transmitted by mosquitoes Aedes aegypti and Aedes albopictus. In Africa, CHIKV is maintained in a sylvatic cycle between animals, mosquitoes and humans. The virus can also be transmitted from mother to child during delivery.

Chikungunya fever, caused by CHIKV, was first identified in Tanzania in 1953. Since 2004 there have been extensive outbreaks throughout Africa and Asia. In 2013 the first cases were identified in the Caribbean, and by September 2014 more than 650,000 cases had been reported in the Americas. Cases of CHIKV infection have also been reported in France, Spain and Italy where the vector is distributed. CHIKV is now recognised as an emerging disease of significant public health concern in these and other regions of the world (CDC).

Chikungunya fever usually starts 2–4 days after infection. Patients present with clinical symptoms that include high fever, rash, headache, vomiting, myalgia, and severe joint pain that may persist for weeks or years (CDC). In some cases, severe cardiac and neurological complications have been reported in infants, the elderly and patients with underlying illness. Transmission of the virus from mother to baby during birth has also been reported, which carries a high risk of morbidity (Morrison, TE).

Diagnosis of CHIKV may be hampered by the fact that clinical symptoms of CHIKV are similar to those seen in cases of Dengue Virus and Zika Virus infection. Therefore, differential diagnosis is an important consideration in areas where flaviviruses such as Dengue and Zika co-circulate. Currently, there is no specific treatment available for the treatment of Chikungunya fever or licensed vaccine for the prevention of CHIKV infection.

References

Centres for Disease Control and Prevention: Chikungunya virus.

Morrison TE. (2014). Reemergence of Chikungunya virus. J. Virol.88:11644-7

Chikungunya Virus Antigens

We offer a range of recombinant antigens for Chikungunya virus studies, prepared using our proprietary mammalian cell expression system. Antigens include our unique virus-like particles (containing E1, E2 and Capsid proteins), and soluble E1 and E2 envelope proteins.

The most recent addition to our Chikungunya range is a recombinant MXRA8 protein, which has been identified as a cell surface receptor mediating CHIKV entry into host cells.

Chikungunya Virus Antibodies

Our range of antibodies specific to Chikungunya virus includes monoclonal antibodies binding capsid protein and E2 envelope protein. We also offer polyclonal antibodies raised against our Chikungunya virus-like particles, which bind capsid, E1 and E2 proteins.

Chikungunya Virus Immunoassays

We are pleased to offer ELISA assays for the detection of antibody response (IgG and IgM) to Chikungunya virus. These assays are suitable for use in laboratory research and development activities and vaccine research studies.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Why We Need Antigen and Antibody Tests for COVID-19

RT-PCR is the workhorse of viral diagnosis and has been invaluable in COVID-19 case confirmation and isolation guidance. However, while fast and sensitive, PCR suffers from some inherent drawbacks that limit it to diagnosis during the acute phase of infection. To...

Gonorrhea: What’s Currently in the Clinical Pipeline?

This article was written by our friends at Infectious Diseases Hub, a free-to-access website that aims to deliver up-to-date, essential research and information on all aspects of microbiology, virology, mycology and parasitology – from bench to bedside....

Novel Coronavirus Antigens Now Available

The Native Antigen Company is now offering recombinant S1 and S2 glycoproteins for SARS-CoV-2 (Covid-19) in response to urgent demand. These reagents are suitable for use in basic research and the development of diagnostics and vaccines.These antigens have been...

The Why and How of Protein Conjugation

In this blog, Lead Assay Development Scientist, Toni Ertl discusses the basics of protein conjugation and introduces our new range of conjugation kits for the labelling of antigens and antibodies.Detecting Proteins If you’re trying to detect or measure the presence...

Going Viral: Why We Need New Diagnostics For a Safe and Effective Dengue Vaccine

This article is taken from European Biopharmaceutical Review January 2020, pages 44-46. © Samedan Ltd.The Dengue VirusDengue is the world’s most prevalent and consequential arboviral disease. Current estimates indicate that as many as 390 million dengue infections...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

15 + 11 =

Live Customer Feedback

Join our mailing list

* indicates required