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West Nile virus

West Nile Virus (WNV) can cause neurological disease and death in people. WNV reached North America in 1999, producing a large and dramatic outbreak that spread throughout the USA in the following years. The WNV outbreak in USA (1999-2010) highlighted the risk from importation of vector-borne pathogens outside of their normal range. Since, the virus has spread and is now widely established from Canada to Venezuela.
At The Native Antigen Company we offer a range of recombinant WNV antigens, and highly specific monoclonal antibodies to support research into the infection and assay development.

West Nile virus background

West Nile Virus (WNV) is an enveloped, single-stranded RNA virus that belongs to the genus Flavivirus. It is a member of the Japanese encephalitis sero-complex of the family Flaviviridae, which also includes Japanese encephalitis virus, St. Louis encephalitis and Murray Valley encephalitis virus. In nature, West Nile virus is maintained in a cycle between birds and mosquitoes. However, WNV can also be transmitted to incidental hosts such as humans, horses and other mammals by mosquito vectors.

Since the first human WNV infection was identified in 1937 the virus has continued to spread. West Nile virus is now found in many regions of the world including Africa, Europe, West Asia, North and South America. WNV infection is asymptomatic in 80% of cases but some individuals develop severe West Nile fever. The symptoms of West Nile fever include fever, headache, nausea and vomiting. The virus has also been associated with neurological complications and fatalities in less than 1% of infected individuals.

Currently, there is no licensed prophylactic vaccine or specific therapeutic treatment for West Nile virus infection in humans. Prevention of WNV infection is through vector control measures and the use of protective clothing to reduce human-to-human transmission.

The Native Antigen Company (NAC) specialises in development and manufacture of native and recombinant viral antigens. Recombinant antigens, developed by NAC, are used by pharmaceutical and IVD manufacturers in vaccine research and serology where proper folding and glycosylation are vital. As well as offering antigens from a rapidly expanding portfolio, NAC undertakes bespoke product development and custom manufacture using its proprietary mammalian cell protein expression system.

Reference

  1. Chancey C, et al (2015). The Global Ecology and Epidemiology of West Nile Virus. Biomed Res Int. 376230.

West Nile virus Antigens

The Native Antigen Company prepare recombinant West Nile virus NS1 protein in a proprietary mammalian cell expression system, which generates highly pure NS1 protein in glycosylated form and predominantly in hexameric format.

West Nile virus Antibodies

We have used our recombinant WNV NS1 protein to raise a panel of specific antibodies to WNV NS1 protein, all of which are highly specific and do not cross-react with NS1 proteins from other flaviviruses, including Dengue, Yellow Fever and Japanese Encephalitis viruses

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