0 Items
Select Page

Oropouche Virus

Oropouche virus (OROV) is one of the most common arboviruses that infects humans in Brazil. It is estimated that since the virus was first isolated in 1955, it has infected more than half a million people. However, it is often mistakenly diagnosed as Dengue, Zika or Chikungunya virus, and therefore true levels of infection are unclear.

The Native Antigen Company offers a range of Oropouche antigens to support the development of assays to reliably detect infection.

Oropouche Virus Background

Oropouche virus (OROV) is an RNA virus, belonging to the family Bunyaviridae. Phylogenetic analysis of OROV has identified 4 virus genotypes (I, II, III, IV), which all occur in Brazil. In humans, OROV causes Oropouche fever, which is clinically characterised by a rapid-onset acute febrile illness. Oropouche fever is reported to be the second most common arboviral disease, next to Dengue fever, in the Brazilian Amazon region. Other symptoms associated with the disease are like those reported for Dengue, Zika, chikungunya, yellow fever and include headache, myalgia, joint pain, nausea and vomiting. In some cases, OROV can cause a form of viral meningitis.

In humans, OROV is transmitted by the biting midge, culicoides paraensis, an insect vector that lives in urban areas and is widely distributed in South America. Since the virus was first isolated in 1955, OROV has caused 30 large-scale epidemics in the Amazon region, infecting at least 500,000 people. The incidence of Oropouche fever has now become widespread in Latin American countries where c. paraensis is present.

Considering the geographical spread of OROV and the similarity of symptoms between Oropouche and fever infections caused by Dengue, Zika, Chikungunya and Yellow Fever viruses, it is important to reliably differentiate between these arboviral diseases with accurate diagnostics.

References

  1. World Health Organization (WHO). Oropouche Virus disease – Peru. http://www.who.int/csr/don/03-june-2016-oropouche-peru/en/
  2. Vasconcelos, H.B. et al (2011). Molecular epidemiology of Oropouche virus, Brazil. Emerg Infect Dis. 17:800-6
  3. Sakkas, H. et al (2018) Oropouche Fever: A Review Viruses 10:175

Oropouche Antigens

In support of Oropouche infection research, we offer a range of antigens relevant to immunoassay and vaccine research. These include OROV Gc and Gn glycoprotiens, expressed in our mammalian cell system and the non-glycosylated nucleoprotein, expressed in E. coli.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

A Q&A with David Flavell of Leukaemia Busters

In this blog, we speak with Dr. David Flavell about his scientific career, the legacy of Leukaemia Busters, and the recent impact that COVID-19 has had on his research.Tell me about your scientific background David. I was born in a seaside town called Southport in...

Avoiding the Immunopathology Pitfalls of a COVID-19 Vaccine

In the second of a three-part series on COVID-19 vaccines, we explore the potential challenges in stimulating safe vaccine responses and outline the role that diagnostics will play in guiding their development.Rogue Responses Antibodies play a crucial role in...

The Bumpy Road to a Cytomegalovirus Vaccine

The development of a cytomegalovirus vaccine has been 50 years in the making. Are there any technologies in the pipeline that could prompt a breakthrough? This article was originally posted online at The Medicine Maker, a Texere publication.To say that...

Why We Need Antigen and Antibody Tests for COVID-19

RT-PCR is the workhorse of viral diagnosis and has been invaluable in COVID-19 case confirmation and isolation guidance. However, while fast and sensitive, PCR suffers from some inherent drawbacks that limit it to diagnosis during the acute phase of infection. To...

Gonorrhea: What’s Currently in the Clinical Pipeline?

This article was written by our friends at Infectious Diseases Hub, a free-to-access website that aims to deliver up-to-date, essential research and information on all aspects of microbiology, virology, mycology and parasitology – from bench to bedside....

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

5 + 1 =

Live Customer Feedback

Join our mailing list

* indicates required