0 Items
Select Page

Hepatitis A

Hepatitis A is a liver disease caused by the hepatitis A virus. The virus is primarily spread when an uninfected (and unvaccinated) person ingests food or water that is contaminated with the faeces of an infected person. The spread of disease is closely linked to unsafe water and food, or inadequate sanitation and poor personal hygiene. Unlike hepatitis B and C, hepatitis A infection does not cause chronic liver disease and is rarely fatal, but can cause debilitating symptoms and fulminant hepatitis (acute liver failure), which is often fatal.

The Native Antigen Company offer a panel of monoclonal antibodies specific to the hepatitis A virus, to facilitate research and assay development.

Hepatitis A Background

Hepatitis A virus (HAV) is a non-enveloped, positive-sense, single stranded RNA virus and member of the Hepatovirus genus of the family Picornaviridae. One serotype and six genotypes, I to VI, of HAV have been defined. Genotypes I, II and III are known to infect humans and are further divided into subtypes A and B. Infection with any of these subtypes provides an individual with lifelong immunity against all HAV viruses that affect humans.

Humans are a natural reservoir for hepatitis A virus. Transmission of occurs primarily via the oral-faecal route through ingestion of HAV contaminated food and water, or through direct contact with an individual infected with HAV. In developing countries, Hepatitis A virus infection commonly occurs in children and is associated with poor sanitation and low socio-economic status. In developed countries, cases of HAV infection may occur in young adults that are in high-risk groups such as care workers, people who inject drugs and individuals travelling from HAV endemic countries.

HAV is thermostable and resistant to treatment with acids, ethers and disinfectants. The hepatitis A virus infects the liver and replicates in hepatocytes, causing liver inflammation. During the incubation stage of HAV infection, an infected individual may be asymptomatic, but virus particles are actively shed and can be present in the patient’s stools. A range of non-specific clinical symptoms may then develop, which include nausea, vomiting, joint pain, malaise, fatigue and fever. Additional symptoms that can occur include cough, pharyngitis, itchiness and hives. As the infection develops, the patient becomes jaundiced and, in some cases, hepatomegaly occurs. The mortality rate associated with HAV infection is low, but complications can lead to acute liver failure and death in a small percentage of cases. Although effective vaccines for the prevention of HAV infection are available, there is currently no specific treatment for patients infected with HAV (WHO).

References

  1. World Health Organization: Hepatitis A, key facts
  2. Hepatitis A Antibodies

Hepatitis A Antibodies

The Native Antigen company offers a range of monoclonal antibodies specific to the hepatitis A virus, offering a panel suitable for the development of immunoassays. These include a Hepatitis A antibody specific to the VP3 capsid polypeptide antigen, which has been shown to have neutralising activity.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Achieving Diagnostic Specificity with Dengue Envelope Domain III

In this blog, we discuss the structure and function of Flavivirus Envelope protein, its ability to elicit a broad range of antibody responses, and present our new range of Dengue virus Envelope DIII proteins for diagnostic and vaccine development.Envelope Protein: A...

Coronaviruses: The Next Disease X?

For much of their known history, the coronaviruses were regarded as relatively benign pathogens with little potential to cause human harm. However, the emergence of SARS and MERS in recent decades has brought coronaviruses into the global spotlight. In this blog we...

Legionella Click Chemistry

In this blog, we introduce our new set of click chemistry reagents for the specific visualisation of Legionella and describe their applications for basic research. Legionella Legionella are a genus of pathogenic gram-negative bacteria found in freshwater and aerated...

Eradicating Malaria: The Role of Diagnostics

Malaria has been a major health threat throughout human history and is still a leading cause of death in many tropical and subtropical countries around the globe. Thanks to renewed efforts over the past two decades, malaria prevalence has reduced by half, making...

The Immune Evasion Strategies of Lassa Fever Virus

In this blog, we outline the molecular pathogenesis of Lassa viral haemorrhagic fever and introduce our extended range of Lassa Fever virus antigens and antibodies.Viral haemorrhagic fevers Viral haemorrhagic fevers (VHF) are a diverse group of viral illnesses that...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

6 + 1 =

Live Customer Feedback

Join our mailing list

* indicates required