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Rotavirus

Rotavirus is a contagious virus that can cause gastroenteritis. Symptoms include severe watery diarrhea, vomiting, fever, and abdominal pain. Infants and young children are most likely to get rotavirus disease. They can become severely dehydrated and need to be hospitalized and can even die.

 

At The Native Antigen Company we have developed a highly specific monoclonal antibody for research studies into Rotavirus infection.

Rotavirus background

The genus rotavirus belongs to the Reoviridae family of viruses. Rotaviruses are non-enveloped, double stranded RNA (dsRNA) viruses that are capable of infecting animals, birds and humans. In the mature virion, a complex triple-layered viral capsid surrounds a genome composed of eleven segments of dsRNA. These RNA segments code for 6 structural and 6 non-structural proteins (CDC). Rotavirus are classified according to the serological reactivity and genetic variability of the structural VP6 protein. Currently, eight species of rotavirus are recognised and are referred to as groups A-H. Group A rotaviruses are the most common cause of human disease, but group B and C rotaviruses have also been found to infect humans.

Rotavirus is transmitted from person-to-person by the faecal oral route via contact with faeces contaminated clothing, surfaces and infected individuals. Occasionally, the virus can also be transmitted via respiratory droplets produced by coughing or sneezing. Rotavirus infection is the most common cause of severe diarrhoea in infants and young children worldwide. Symptoms of rotavirus infection include lethargy, fever, vomiting, abdominal pain, severe watery diarrhoea and dehydration. Severe dehydration can often lead to hospitalization and in some cases death. Rotavirus infection in older children and adults may be mild or even asymptomatic.

Effective vaccines are available which have helped to reduce severe diarrhoea and childhood mortality, caused by rotavirus infection. However, rotavirus continues to have a major global impact on childhood morbidity and mortality, particularly in developing countries (WHO).

References

Centers for Disease Control and Prevention: Rotavirus

World health organization: Rotavirus

Rotavirus Antibodies

Our monoclonal antibody, clone R15, is specific for the VP6 structural protein of rotavirus. The antibody does not cross react with other organisms causing gastrointestinal infection, including Campylobacter spp., Clostridium difficile, Escherichia coli, Listeria monocytogenes, Salmonella spp., Shigella spp., Yersinia enterocolitica, Enterovirus, Norovirus, Astrovirus, Adenovirus, Cryptosporidium parvum, Giardia lamblia, Helicobacter pylori, Entamoeba histolytica, Staphylococcus aureus.

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