0 Items
Select Page

Borrelia

Borrelia infection can cause the condition known as Lyme disease or Lyme borreliosis. In humans, the most common clinical manifestation of infection is a large red rash (erythema migrans), which varies in its size and appearance, and generally resolves without treatment.

The Native Antigen Company provides monoclonal antibodies, antigens and immunoassays specific to Borrelia garinii, B. afzelii, or B. burgdorferi sensu stricto which are ideal for use in a wide range of research studies.

Borrelia Background

Five Borrelia species have been reported to infect humans, including B. burgdorferi sensu stricto in North America and Europe, B. garinii, B. bavariensis, B. afzelii in Europe and Asia, and B. spielmanii in Europe. B. afzelii and B. garinii account for most cases of Lymes disease in Europe (Wang, G.), which are transmitted by the hard tick Ixodes Ricinus and maintained in small vertebrates and birds. They all belong to the Borrelia burgdorferi sensu lato species complex of spirochetes of the genus Borrelia, family Spirochaetaceae. In nature, spirochetes are maintained in a transmission cycle between hard ticks of the Ixodes species and a reservoir of small-medium sized vertebrate, and in some cases birds. In humans, infection occurs through the bite of a tick infected with the spirochete. Infection with Borrelia in humans can cause a condition known as Lyme disease or Lyme borreliosis.

In humans, the most common clinical manifestation of infection is a large red rash, referred to as erythema migrans, which can vary in size and appearance. Additional symptoms include fever, chills, headache, fatigue, joint pains and swollen lymph nodes. However, in some severe cases, the infection may spread to joints, the nervous system or heart and clinical symptoms including neck stiffness, arthritis, facial palsy, heart palpitations, nerve pain, numbness and memory loss may develop (CDC). Erythema migrans generally resolves without treatment. However, patients with Lyme disease are often treated with antibiotics to prevent dissemination and potential development of more severe clinical symptoms. Currently, no licensed vaccine to prevent Borrelia infection is available.

References

  1. Wang G, Liveris D, Mukherjee P, Jungnick S, Margos G, Schwartz I. 2014. Molecular Typing of Borrelia burgdorferi. Curr Protoc Microbiol. Aug 1;34:12C.5.1-31
  1. Centers for Disease Control and Prevention: Lyme Disease

 

Borrelia Antigens

We offer an extensive range of Borrelia antigens, expressed as recombinant proteins in E. coli.

These antigens are suitable for use in assay development, vaccine research and as antigens for the preparation of Borrelia-specific antibodies.

Borrelia Immunoassays

We are pleased to offer ELISA assays for the detection of antibody response (IgG and IgM) to Borrelia burgdorferi. These assays are suitable for use in laboratory research and development activities and vaccine research studies.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Diagnosing HIV in resource-limited settings

In this blog, we discuss the need for improved point-of-care (PoC) diagnostics for HIV and present the virus's cellular mechanism to illustrate our new range of HIV antigens and antibodies. HIV in the developed world On June 5th 1981 in Los Angeles, California, 5...

Our Product Pipeline

If you’ve been following us on social media recently, you might have noticed that we’ve been releasing a lot of new antigens and antibodies. In this blog, we explain how we use the WHO R&D Blueprint to guide our product development and present some highlights from...

From Outbreak to Epidemic: A Short History of The Ebola Virus

In the first of a two-part series, we discuss the history of the Ebola virus up to the ongoing outbreak in the Democratic Republic of Congo, and why this disease has been so challenging to fight. The 2014/15 epidemic In the summer of 2014, the world watched as the...

ELISA Formats for Infectious Disease Diagnostics

The field of diagnostics is rapidly developing, yet ELISA and PCR methods remain the most commonly used techniques in the diagnosis of bacterial and viral infections. In this blog, we discuss the advantages of using serological methods over molecular, PCR-based...

The world’s most extensive range of NS1-specific antibodies for flavivirus research

The Native Antigen Company first gained prominence in 2016, when it developed highly pure Zika virus NS1 protein during the 2015/2016 epidemic. Since then, the company has developed an extensive range of highly specific antigens, antibodies and immunoassays for...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

6 + 11 =

Live Customer Feedback

Join our mailing list

* indicates required