0 Items
Select Page

Filovirus Receptors

The Native Antigen Company manufacturers highly purified virus-host cell receptors using state-of-the-art expression and purification techniques. On request we can also undertake custom preparation of recombinant and native proteins for a broad range of disease states.

Filovirus Receptors Background

The family Filoviridae contains several related viruses (filoviruses or filovirids) that form filamentous infectious viral particles (virions), and encode single-stranded negative-sense RNA genomes. Family members include Ebola virus and Marburg virus (both biosafety level 4 agents), which cause severe disease in humans and non-human primates in the form of viral haemorrhagic fevers. Filoviruses are an ancient family and are likely to have an evolutionary history of tens of millions of years. Endogenous virus sequences that appear to be derived from filovirus-like viruses have been identified in the genomes of bats, rodents, shrews, tenrecs, tarsiers and marsupials.

The filovirus envelope glycoprotein (GP) is responsible for both receptor binding and fusion of the virus envelope with the host cell membrane. Since GP is the only viral surface GP, it is believed to play an important role in controlling the tropism and pathogenesis of filovirus infection. The mucin-like region (MLR) on GP interacts with multiple molecules for entry into host cells, although none of the interactions identified to date fully explains the breadth of filovirus tissue tropism and host range.

Filoviruses show broad tissue tropism and hepatocytes, endothelial cells, dendritic cells, monocytes, and macrophages are thought to be their preferred target cells. Members of the Tyro3 receptor tyrosine kinase family (Axl, Dtk, and Mer) have been shown to be involved in cell entry of filoviruses. Other candidate molecules believed to play a role in filovirus entry include human folate receptor-α, endo/lysosomal cholesterol transporter protein Niemann–Pick C1 (NPC1) and C-type lectins.

However, although it is known that Filoviruses utilize multiple molecules for their entry into cells, it is still unclear which of these molecules serve as functional receptors mediating both viral attachment and membrane fusion or play independent roles, as either attachment receptors or fusion receptors.

Filovirus Receptors

We offer a range of filovirus receptors comprising highly purified recombinant proteins known to bind to a broad spectrum of viruses.

 

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Achieving Diagnostic Specificity with Dengue Envelope Domain III

In this blog, we discuss the structure and function of Flavivirus Envelope protein, its ability to elicit a broad range of antibody responses, and present our new range of Dengue virus Envelope DIII proteins for diagnostic and vaccine development.Envelope Protein: A...

Coronaviruses: The Next Disease X?

For much of their known history, the coronaviruses were regarded as relatively benign pathogens with little potential to cause human harm. However, the emergence of SARS and MERS in recent decades has brought coronaviruses into the global spotlight. In this blog we...

Legionella Click Chemistry

In this blog, we introduce our new set of click chemistry reagents for the specific visualisation of Legionella and describe their applications for basic research. Legionella Legionella are a genus of pathogenic gram-negative bacteria found in freshwater and aerated...

Eradicating Malaria: The Role of Diagnostics

Malaria has been a major health threat throughout human history and is still a leading cause of death in many tropical and subtropical countries around the globe. Thanks to renewed efforts over the past two decades, malaria prevalence has reduced by half, making...

The Immune Evasion Strategies of Lassa Fever Virus

In this blog, we outline the molecular pathogenesis of Lassa viral haemorrhagic fever and introduce our extended range of Lassa Fever virus antigens and antibodies.Viral haemorrhagic fevers Viral haemorrhagic fevers (VHF) are a diverse group of viral illnesses that...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

7 + 15 =

Live Customer Feedback

Join our mailing list

* indicates required