0 Items
Select Page

Tick-Borne Encephalitis

Tick-borne encephalitis virus (TBEV) causes 13,000 cases of human meningitis and encephalitis annually. Mortality varies depending on the sub-type, but long-term neuropsychiatric disorders can occur in a significant proportion of patients.

The Native Antigen Company offers recombinant TBEV proteins developed from our proprietary mammalian expression system alongside monoclonal antibodies and immunoassays.

TBEV Background

Tick-borne Encephalitis virus (TBEV) is primarily transmitted through the bite of infected hard ticks, of the family Ixodidae. Small rodents are the primary hosts for TBEV, with humans acting as accidental hosts. The virus can also be transmitted to humans through unpasteurized milk in areas where TBEV is prevalent (CDC).

TBEV is a neurotrophic virus that causes tick-born encephalitis (TBE) in humans, affecting the central nervous system (CNS). TBE is endemic in many parts of Europe, China, Mongolia and the Russian Federation, and is the most common tick-borne CNS infection in these areas (WHO). Three subtypes of TBEV have been recognised that cause TBR, which are European, Far-Eastern and Siberian.

TBEV infection is asymptomatic in most cases with some individuals presenting with influenza-like symptoms. In symptomatic cases, TBEV infection typically presents as meningitis, encephalitis or meningoencephalitis. A high percentage of acute TBE cases may also develop post-encephalitic syndrome with long-lasting neuropsychiatric symptoms or neurological dysfunction (Bogovic, P).

Diagnosis of TBE infection is primarily based on clinical presentation and serological testing for TBEV-specific IgM and IgG antibodies in patient sera and cerebrospinal fluid. There is no anti-viral treatment for TBEV. However, several effective vaccines for TBEV are currently available which are based on European and Far-Eastern strains of the virus (WHO).

Tick-Borne Encephalitis Antigens

The Native Antigen Company prepares recombinant TBEV proteins in its proprietary mammalian cell expression system, including highly pure NS1 protein, in its glycosylated and predominantly hexameric format.

Tick-Borne Encephalitis Antibodies

The Native Antigen Company is pleased to offer a full panel of monoclonal antibodies to TBEV antigens, which are suitable for the development of specific immunoassays. These antibodies have been tested against our renowned mammalian-expressed, recombinant proteins, and are suitable for use in both ELISA and Western blot applications.

 

Tick-Borne Encephalitis Immunoassays

We are pleased to offer ELISA assays for the detection of antibody response (IgG and IgM) to Tick-borne encephalitis virus. These assays are suitable for use in laboratory research and development activities and vaccine research studies.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Diagnosing HIV in resource-limited settings

In this blog, we discuss the need for improved point-of-care (PoC) diagnostics for HIV and present the virus's cellular mechanism to illustrate our new range of HIV antigens and antibodies. HIV in the developed world On June 5th 1981 in Los Angeles, California, 5...

Our Product Pipeline

If you’ve been following us on social media recently, you might have noticed that we’ve been releasing a lot of new antigens and antibodies. In this blog, we explain how we use the WHO R&D Blueprint to guide our product development and present some highlights from...

From Outbreak to Epidemic: A Short History of The Ebola Virus

In the first of a two-part series, we discuss the history of the Ebola virus up to the ongoing outbreak in the Democratic Republic of Congo, and why this disease has been so challenging to fight. The 2014/15 epidemic In the summer of 2014, the world watched as the...

ELISA Formats for Infectious Disease Diagnostics

The field of diagnostics is rapidly developing, yet ELISA and PCR methods remain the most commonly used techniques in the diagnosis of bacterial and viral infections. In this blog, we discuss the advantages of using serological methods over molecular, PCR-based...

The world’s most extensive range of NS1-specific antibodies for flavivirus research

The Native Antigen Company first gained prominence in 2016, when it developed highly pure Zika virus NS1 protein during the 2015/2016 epidemic. Since then, the company has developed an extensive range of highly specific antigens, antibodies and immunoassays for...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

7 + 10 =

Live Customer Feedback

Join our mailing list

* indicates required