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Isotype controls

Isotype controls are a type of negative control designed to measure the level of non-specific background signal caused by primary antibodies. The background signal is often the result of immunoglobulins binding non-specifically to Fc receptors present on the cell surface. For example, antibodies raised in mice may bind to some human cells regardless of the test antibody specificity, in a manner related to the isotype of the antibody being used. In these cases you need an isotype control of the same isotype as the test antibody to provide a relevant control for non-specific binding.

Isotype control antibodies

We offer a range of isotype control antibodies that match our primary antibodies, allowing customers to select the appropriate control for their own experimental system.

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Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Zika Prevalence in Suriname – an insight into assay cross-reactivity

A recent study published by Langerak et al tested for the seroprevalence of Zika virus in Suriname populations and evaluated the comparative effectiveness of using a commercial ELISA and a standard Virus Neutralisation Assay. Here we discuss the study, its results,...

What should you call your favourite virus?

The International Committee on Taxonomy of Viruses (ICTV) meet regularly to ensure the taxonomy of viruses is kept logical and up-to-date in the face of an ever-increasing number of new viruses and genome sequences; discussed in here in Nature. This sometimes results...

Overcoming Zika-Dengue cross-reactivity: the highly specific immunoassays your lab needs

In the global battle against Zika virus, serological cross-reactivity with Dengue is a major challenge for academics, epidemiologists and pharmaceutical companies alike. Novel immunoassays can now overcome this problem and could prove a real game-changer in Zika...

The Right Tools for Rubella

Rubella remains a significant pathogen worldwide, with 100,000 cases of congenital rubella syndrome estimated to occur every year. Vaccines to Rubella are highly safe and have effectively eliminated endemic infection in many developed countries, yet inadequate...

Visualising viral infection with immunofluorescence microscopy

Following the latest immunofluoresence data for our Zika and Dengue antibodies, we’ve invited VRS to write a short blog one of their areas of expertise: The applications of immunofluorescence microscopy in studying viruses.   A lot of what we know about biology...

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