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Adenovirus

Having been founded by virologists specialising in Adenoviruses we offer in-depth expertise both in catalogues reagents and for customised Adenovirus preparations.

We supply purified adenovirus antigens alongside monoclonal antibodies to Adenovirus hexon protein. On request we can also undertake custom preparation of adenoviruses from a number of strains, including constructs expressing GFP, LUC and other proteins.

Adenovirus background

Human Adenoviruses (HAdV) are non-enveloped, non-segmented double stranded DNA viruses, belonging to the genus Mastadenovirus within the Adenoviridae family of viruses. Human Adenoviruses have been further classified into seven species groups A- G. Since the discovery of adenovirus in human adenoid tissue in 1953, by Wallace Rowe and colleagues, more than 50 serotypes of human adenovirus and 70 genotypes have been identified (Cook, J) .

Human adenoviruses are globally widespread and ubiquitous in the environment. HAdV can persist in the environment and is resistant to most household disinfectants. Transmission of HAdV occurs primarily via the faecal-oral route, with contaminated water and food being the source of infection. HAdV may also be spread through contact with contaminated surfaces and through aerosol droplets from an infected individual.

Human adenoviruses commonly cause respiratory disease but some HAdV serotypes cause gastrointestinal disease, conjunctivitis and cystitis. The clinical disease caused by HAdV infection varies depending on the HAdV type. In immunocompromised patients, HAdV infection can cause severe clinical symptoms that may lead to respiratory failure, neurological disease and death.

Currently there is no specific treatment for HAdV infection, which is mild and self-limiting in most cases, and licensed vaccines are not available for prophylactic treatment of the general public (CDC).

References

  1. Cook J, Radke J. (2017). Mechanisms of pathogenesis of emerging adenoviruses. F1000Res. Jan 30;6:90. PMID: 28184296
  2. Centers for Disease Control and Prevention: Adenoviruses

Adenovirus Antigens

Our range of adenovirus antigens includes a highly purified preparation of Ad40 particles, alongside purified hexon protein from both Ad5 and Ad40.

The adenovirus hexon protein is a major component of the adenovirus capsid. Hexon proteins readily form trimers, and can then further self-assemble into capsomeres of 240 hexons.

 

Adenovirus Antibodies

We offer a pair of monoclonal antibodies that are specific for the hexon protein of Adenovirus. Hexon protein is the largest and most abundant structural protein in the adenovirus capsid. The antibodies are suitable for use in ELISA, and can be used as a piar in immunoassay development.

Both antibodies recognise hexon protein from all strains of adenovirus that have been tested, including strains 2, 3, 4, 5, 15, 31, 40 and 41.

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