0 Items
Select Page

Nipah Virus

Nipah virus (NiV) is a zoonotic virus (transmitted from animals to humans) and can be further transmitted through contaminated food or directly between people. In infected people, it causes a range of illnesses from asymptomatic (subclinical) infection to acute respiratory illness and fatal encephalitis. The virus can also cause severe disease in animals such as pigs, resulting in significant economic losses for farmers. Although Nipah virus has caused only a few known outbreaks in Asia, it infects a wide range of animals and causes severe disease and death in humans, making it a public health concern.

We offer recombinant Nipah virus proteins in support of vaccine R&D and as targets for serological immunoassays.

Nipah Virus Background

Nipah virus (NiV) is an enveloped, single-stranded negative-sense RNA virus that belongs to the Henipavirus genus – a new member of the Paramyxoviridae family. Nipah infection was first recognised in Malaysia 1998/1999, where a major NiV outbreak occurred in pigs and humans. A subsequent outbreak of NiV in Singapore also pointed to pigs as an intermediate host. However, other outbreaks in India and Bangladesh did not. The natural host for NiV has now been identified as the fruit bat, of the Pteropus genus, with swine acting as intermediate host in some cases. Reports suggest that transmission of Nipah virus to humans can occur through contact with NiV infected bats, food contaminated by bat’s excrement, infected pigs and other NiV infected humans. Two different clades of NiV have been identified to date (I and II), suggesting different routes of transmission. NiV infection has also been reported in other animals such as dogs, cats, horses and goats but these are thought to be dead-end hosts (CDC).

Nipah, the disease caused by NiV infection is now endemic in South Asia and several outbreaks of NiV infection have been reported in India and Bangladesh. Nipah is a zoonotic disease with high rates of morbidity and mortality in infected animals and humans. The symptoms of Nipah virus infection in humans can include rapidly developing fever, abdominal pain, nausea, vomiting, acute respiratory syndrome and severe encephalitis, which is fatal in a high percentage of cases (WHO).

In 2015, the World Health Organization highlighted NiV infection as an emerging disease, requiring accelerated R&D to advance in vitro diagnostic development, vaccine design and therapeutics (WHO, 2015).

References

  1. Centers for Disease Control and Prevention: Nipah Virus (NiV)
  2. World Health Organization: Nipah Virus (NiV) infection
  3. World Health Organization: WHO publishes list of top emerging diseases likely to cause major epidemics

Nipah Antigens

Our proprietary mammalian cell expression system is used to prepare recombinant Nipah virus glycoprotein F and glycoprotein G, suitable for use in assay development, vaccine research and as antigens for the preparation of nipah-specific antibodies. These proteins are presented as Fc-fusion proteins, with an option of either human or mouse Fc regions to maximise flexibility.

Nipah Antibodies

The Native Antigen Company provides a range of monoclonal mouse antibodies against Nipah virus Glycoproteins F and G. These antibodies are suitable for the development of vaccines, therapeutics and immunoassays, showing minimal cross-reactivity with other serotypes.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Why We Need Antigen and Antibody Tests for COVID-19

RT-PCR is the workhorse of viral diagnosis and has been invaluable in COVID-19 case confirmation and isolation guidance. However, while fast and sensitive, PCR suffers from some inherent drawbacks that limit it to diagnosis during the acute phase of infection. To...

Gonorrhea: What’s Currently in the Clinical Pipeline?

This article was written by our friends at Infectious Diseases Hub, a free-to-access website that aims to deliver up-to-date, essential research and information on all aspects of microbiology, virology, mycology and parasitology – from bench to bedside....

Novel Coronavirus Antigens Now Available

The Native Antigen Company is now offering recombinant S1 and S2 glycoproteins for SARS-CoV-2 (Covid-19) in response to urgent demand. These reagents are suitable for use in basic research and the development of diagnostics and vaccines.These antigens have been...

The Why and How of Protein Conjugation

In this blog, Lead Assay Development Scientist, Toni Ertl discusses the basics of protein conjugation and introduces our new range of conjugation kits for the labelling of antigens and antibodies.Detecting Proteins If you’re trying to detect or measure the presence...

Going Viral: Why We Need New Diagnostics For a Safe and Effective Dengue Vaccine

This article is taken from European Biopharmaceutical Review January 2020, pages 44-46. © Samedan Ltd.The Dengue VirusDengue is the world’s most prevalent and consequential arboviral disease. Current estimates indicate that as many as 390 million dengue infections...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

6 + 7 =

Live Customer Feedback

Join our mailing list

* indicates required