0 Items
Select Page

Nipah Virus

Nipah virus (NiV) is a zoonotic virus (transmitted from animals to humans) and can be further transmitted through contaminated food or directly between people. In infected people, it causes a range of illnesses from asymptomatic (subclinical) infection to acute respiratory illness and fatal encephalitis. The virus can also cause severe disease in animals such as pigs, resulting in significant economic losses for farmers. Although Nipah virus has caused only a few known outbreaks in Asia, it infects a wide range of animals and causes severe disease and death in humans, making it a public health concern.

We offer recombinant Nipah virus proteins in support of vaccine R&D and as targets for serological immunoassays.

Nipah Virus Background

Nipah virus (NiV) is an enveloped, single-stranded negative-sense RNA virus that belongs to the Henipavirus genus – a new member of the Paramyxoviridae family. Nipah infection was first recognised in Malaysia 1998/1999, where a major NiV outbreak occurred in pigs and humans. A subsequent outbreak of NiV in Singapore also pointed to pigs as an intermediate host. However, other outbreaks in India and Bangladesh did not. The natural host for NiV has now been identified as the fruit bat, of the Pteropus genus, with swine acting as intermediate host in some cases. Reports suggest that transmission of Nipah virus to humans can occur through contact with NiV infected bats, food contaminated by bat’s excrement, infected pigs and other NiV infected humans. Two different clades of NiV have been identified to date (I and II), suggesting different routes of transmission. NiV infection has also been reported in other animals such as dogs, cats, horses and goats but these are thought to be dead-end hosts (CDC).

Nipah, the disease caused by NiV infection is now endemic in South Asia and several outbreaks of NiV infection have been reported in India and Bangladesh. Nipah is a zoonotic disease with high rates of morbidity and mortality in infected animals and humans. The symptoms of Nipah virus infection in humans can include rapidly developing fever, abdominal pain, nausea, vomiting, acute respiratory syndrome and severe encephalitis, which is fatal in a high percentage of cases (WHO).

In 2015, the World Health Organization highlighted NiV infection as an emerging disease, requiring accelerated R&D to advance in vitro diagnostic development, vaccine design and therapeutics (WHO, 2015).

References

  1. Centers for Disease Control and Prevention: Nipah Virus (NiV)
  2. World Health Organization: Nipah Virus (NiV) infection
  3. World Health Organization: WHO publishes list of top emerging diseases likely to cause major epidemics

Nipah Antigens

Our proprietary mammalian cell expression system is used to prepare recombinant Nipah virus glycoprotein F and glycoprotein G, suitable for use in assay development, vaccine research and as antigens for the preparation of nipah-specific antibodies. These proteins are presented as Fc-fusion proteins, with an option of either human or mouse Fc regions to maximise flexibility.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Challenges to Effective Yellow Fever Diagnostics

Yellow fever is a haemorrhagic viral disease, transmitted by infected mosquitos in Africa and South America. While an effective vaccine is available, inadequate vaccination of endemic areas has made diagnostics a necessity to controlling ongoing outbreaks. However,...

Five Methods You Can Use to Overcome Zika-Dengue Cross-Reactivity

Cross-reactivity between the Zika and Dengue viruses in serological assays is one of the biggest challenges faced by the epidemiologists, academics and pharmaceutical companies trying to control the Zika epidemic, as it brings the quality and reliability of diagnostic...

Why Zika virus’s cross-reactivity with Dengue might be hampering your research

Given the impact of Zika, it’s no surprise that a global contingent of epidemiologists, academic researchers, and pharmaceutical companies are striving to develop effective disease control measures and treatments. One challenge currently hindering the...

How The Native Antigen Company responds to the WHO list of priority infectious diseases

In 2015, a broad group of public health and science experts gathered in Geneva to discuss emerging infectious diseases that are likely to cause future severe epidemics and public health emergencies. Organised by the World Health Organization (WHO), their aim was to...

Native Antigen release a panel of serotype specific monoclonal antibodies

  There are four distinct serotypes of Dengue Virus circulating around the world, causing Dengue fever infection which is the most important worldwide arboviral disease. There are nearly 400 million cases of Dengue annually, and around 25% present with so called...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

7 + 12 =

Live Customer Feedback