The Native Antigen Company is part of LGC Clinical Diagnostics - Learn More

0 Items
Select Page

Hepatitis E

Hepatitis E virus (HEV) is a small positive sense, single-stranded RNA virus. HEV is currently the only representative of the hepevirus genus, belonging to the family Hepeviridae. Four genotypes 1-4 of the Hepatitis E virus have been identified so far, with each genotype having a different geographical distribution. Transmission of HEV primarily occurs via the faecal-oral route, through contaminated food or water, but can be transmitted through blood transfusion products in some cases.

In healthy individuals, Hepatitis E is an asymptomatic or self-limiting disease. However, patient with a pre-existing chronic liver disease and pregnant women have an increased risk of liver failure and death. Diagnosis of HEV is achieved using serological and molecular methods of detection.

Hepatitis E Background

Hepatitis E virus (HEV) is a small positive sense, single-stranded RNA virus. HEV is currently the only representative of the hepevirus genus, belonging to the family Hepeviridae. Four genotypes 1-4 of the Hepatitis E virus have been identified so far, with each genotype having a different geographical distribution. HEV genotype 1 and 2 are restricted to humans and are found in Africa and Asia, whereas genotype 3 is found worldwide and genotype 4 is found in China and Japan. Both genotypes 3 and 4 generally circulate in animals including pigs, wild boar, deer and rabbits but can also infect humans (WHO).

Transmission of HEV primarily occurs via the faecal-oral route, through contaminated food or water. Infection through contaminated water is a typical route of transmission for HEV genotypes 1 and 2, particularly in endemic areas with poor sanitation. Infections involving HEV genotypes 3 and 4 have been linked to the consumption of undercooked pork and meat from infected animals. Reports suggest that HEV may also be transmitted via transfused blood products in areas where the virus is endemic.

In healthy individuals, Hepatitis E is an asymptomatic or self-limiting disease which can last for up to two weeks after the incubation period of 2-9 weeks. Symptoms can include fatigue, nausea, loss of appetite, abdominal pain, aching joints, slight hepatomegaly and numbness in arms and legs. Immunosuppressed patients infected with HEV may develop chronic liver disease after initial infection. In addition, patient with a pre-existing chronic liver disease and pregnant women have an increased risk of liver failure and death. Reports suggest that the risk of miscarriage, liver failure and death can increase during the second and third trimester of pregnancy.

HEV infection emerging as a significant disease of global health concern. Currently there is no effective treatment for HEV infection, although Ribavirin has been shown. to benefit immunosuppressed patients. A single vaccine has been developed and licensed for the prevention of HEV infection, which is under review by the World Health Organization.

 

References

World Health Organization: Fact sheets; Hepatitis E

Hepatitis E Antigens

Our Hepatitis E antigens include highly purified preparations of ORF2 with different purification tags. These antigens are suitable for use in assay development, vaccine research and for the preparation of Hepatitis E antibodies.

Hepatitis E Antibodies

Our monoclonal Hepatitis E antibodies target the HEV capsid (ORF2) and are suitable for use in diagnostic assay development and vaccine research.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

Monkeypox; 3 months on

It has been 3 months since a new, unusually widespread outbreak of Monkeypox was first identified. What was normally a virus confined to limited infections in the West African continent is becoming a global health concern.   What have we learned about this virus...

COVID-19 Underlines the Need for Universal Vaccines

This article was originally published on Clinical Lab Manager. In recent history, humanity has witnessed numerous emerging viral diseases, including the SARS, MERS, and SARS-2 coronaviruses, as well as HIV, Zika, Ebola, and H1N1 and H3N2 influenza. None have tested...

Tick-Borne Diseases: The Need for Integrated Approaches to Human-Animal Diagnosis

This article has been published in Volume 8, Issue 3 of International Animal Health Journal. Ticks are responsible for a diverse group of neglected, and rapidly expanding diseases, affecting humans, companion animals and livestock. A growing understanding of tick-host...

The Continued Challenges of Flavivirus Serology

This article was originally published on the Science Advisory Board. Flaviviruses are a genus of positive-sense RNA viruses, largely transmitted by mosquito and tick vectors that cause infections, including yellow fever, dengue, the Zika virus, West Nile virus,...

The Role of Serology in Tracking COVID-19 Mutations

This article was originally published on Clinical Lab Products. As SARS-CoV-2 began its global proliferation in early 2020, scientists hastened to investigate its biology, develop diagnostic tests, and design candidate vaccines, marking one of the most...

Get in Touch

We sometimes send exclusive information and offers to our customers - please let us know if you are happy to receive these

10 + 7 =