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Listeria

Listeria monocytogenes is the causative agent of a rare but severe and life threatening food-borne disease known as listeriosis. In most people, Listeria monocytogenes infection may cause a self-limiting febrile illness. In pregnant women, newborn babies and immunocompromised people, the disease can cause severe illness or even death. Although the number of annual reported cases of Listeriosis are relatively small, the high risk of mortality in these individuals is of significant global health concern.

To support Listeria monocytogenes research, we have developed antibodies that work together as a matched pair in ELISA assays, and are suitable for immunoassay research and development.

Listeria Background

Listeria monocytogenes is the causative agent of a severe and life-threatening food-borne disease known as listeriosis.

In nature, L. monocytogenes (Lm) is ubiquitous in soil, water, animal waste and decaying plants, where it acts as a saprophyte. Transmission of Lm to humans can occur via a diverse range of food types including pre-cooked contaminated meat, unpasteurised dairy products, soft cheese, vegetables, fruit and undercooked ready-to-eat food products.

In healthy adults, Lm infection may be asymptomatic or cause a self -limiting flu-like illness with vomiting and diarrhoea. However, in the elderly, newborn infants and immunocompromised individuals, invasive L.monocytogenes infection can occur leading to life-threatening diseases such as meningitis and septicaemia. In pregnant women, infection of the foetus in utero can cause spontaneous abortion (CDC).

Although the number of annual reported cases of Listeriosis are relatively small, most patients with listeriosis require hospitalisation and the risk of death is high in these cases. In addition, Lm infection is the reported to be the third leading cause of foodborne death and is therefore a global health concern.

References

Centers for Disease Control and Prevention: Listeria (Listeriosis)

Listeria Antibodies

The Native Antigen Company supply monoclonal antibodies designed for Listeria monocytogenes immunoassay research and development. Our monoclonal antibodies MAB12259 (clone LZF7) and MAB12260 (clone LZH1) work together as a capture- detection antibody pair in sandwich immunoassays.

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