Human Follicle-stimulating Hormone (subunit alpha+beta), Recombinant

Human follicle-stimulating hormone (FSH), subunit Alpha+Beta, produced in HEK293 cells and purified by affinity chromatography and dialysis.

PRODUCT DETAILS –

Human Follicle-stimulating Hormone (subunit alpha+beta), Recombinant

• Accession: P01215, P01225
• Tag: His-tag / 2xStrep-tag, C-Terminus
• Expressed and purified from HEK293 cells
• Presented as liquid in DPBS

BACKGROUND

Follicle-stimulating hormone (FSH) is a critical glycoprotein hormone secreted by the anterior pituitary gland, essential for regulating reproductive function in both males and females. Structurally, FSH is composed of a shared alpha subunit and a unique beta subunit, which confers receptor specificity by binding to FSH receptors in ovarian granulosa cells and testicular Sertoli cells. This interaction regulates ovarian follicle maturation and spermatogenesis, respectively (Dias et al., 2010). Clinically, FSH measurements are integral to diagnosing infertility, assessing gonadal function, and managing conditions like polycystic ovary syndrome (PCOS) and primary ovarian insufficiency (Griswold, 2016).

While traditional FSH assays suffer from variability due to heterogeneity in glycosylation and protein sourcing, recombinant FSH, produced via recombinant DNA technology, has brought notable improvements. These include batch consistency, high purity, and defined bioactivity, making recombinant FSH the preferred option in assisted reproductive technologies (ART) and ovulation induction protocols (Out et al., 1997).

Our recombinant FSH offers a consistent, high-purity reference standard ideal for use as a control or calibrator in FSH diagnostic kits, improving assay reliability and accuracy for infertility diagnosis, gonadal function assessment, and reproductive disorder management—ultimately enhancing patient care across diagnostic platforms.

References

Dias, J. A., Ulloa-Aguirre, A., & Crépieux, P. (2010). Signal transduction by the FSH receptor. Annual Review of Pharmacology and Toxicology, 50, 147-172.

Griswold, M. D. (2016). The central role of Sertoli cells in spermatogenesis. Cold Spring Harbor Perspectives in Biology, 8(1), a025814.

Out, H. J., Mannaerts, B. M., & Coelingh Bennink, H. J. (1997). A comparison of recombinant and urinary human follicle stimulating hormone for ovarian stimulation. Human Reproduction Update, 3(3), 223-231.