RABBIT ANTI-DENGUE VIRUS PAN SEROTYPE NS1 POLYCLONAL ANTIBODY

This rabbit anti-pan Dengue NS1 polyclonal antibody recognizes NS1 for all four types of Dengue viruses.

PRODUCT DETAILS – RABBIT ANTI-DENGUE VIRUS PAN SEROTYPE NS1 POLYCLONAL ANTIBODY

• Rabbit anti-Dengue virus pan serotype NS1 polyclonal antibody.
• Immunogen was a recombinant DENV-2 NS1 protein expressed from insect cells.
• Purified to high purity by antigen-affinity chromatography and presented in DPBS.
• Rabbit anti-pan Dengue NS1 also recognizes Zika virus NS1.
• Suitable for use in immunoassays.

BACKGROUND

Dengue virus (DENV) is a single positive strand RNA virus of the Flaviviridae family and a causative agent of the infectious tropical disease Dengue fever. There are four serotypes of the virus, DENV-1, DENV-2, DENV-3 and DENV-4. Dengue NS1 (Non-Structural protein 1) is a versatile glycoprotein of the DENV that is secreted as a hexamer, binds to the cell surface, and has immune evasive functions. Dengue NS1 antigen is also used as an early detection marker (days 1 to 9 after onset) for dengue virus infection.

Dengue fever is ranked by the World Health Organization (WHO) as the most critical mosquito-borne viral disease, globally. More than 40 percent of the world’s population, in more than 100 countries are at risk of dengue infection. The most significant dengue epidemics in recent years have occurred in Southeast Asia, the Americas and the Western Pacific. Each year, an estimated 390 million dengue infections occur around the world. Of these, 500,000 cases develop into dengue haemorrhagic fever – a more severe form of the disease, which results in up to 25,000 deaths annually.

With more than one-third of the world’s population living in areas at risk of transmission, dengue infection is a leading cause of illness and death in the tropics and subtropics (WHO for Guidelines for Diagnosis, Treatment, Prevention & Control, 2009). As many as 100 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are no vaccines available to prevent infection with dengue virus.