New Norovirus-Like Particles Available

To support norovirus research and development, The Native Antigen Company offers 6 new norovirus-like particles, produced from our proprietary VirtuE™ mammalian expression system.

Our Norovirus-Like Particles

Virus-like particles (VLPs) comprise the structural proteins of a viral particle, but don’t contain genomic material, making them non-infectious, while presenting all of the structural epitopes of a native virus. Because of these properties, VLPs have been extensively used in diagnostic and vaccine R&D over recent years.

To support norovirus research and development, The Native Antigen Company offers an extended range of 8 norovirus-like particles, produced from our proprietary VirtuE™ (HEK293) and insect-baculovirus expression systems.

Norovirus Electron Micrographs: negative stain EM of norovirus GI.1 VLPs produced by The Native Antigen Company, showing intact particles.

Our norovirus VLPs are comprised of VP1 proteins, that self-assemble as an icosahedron of 180 subunits. VP1 is a 59kDa glycoprotein with three key domains: The shell domain (S domain) contains elements essential for the formation of the icosahedron. The Protruding domain (P domain) is divided into sub-domains P1 and P2. The P domain interacts in dimeric contacts that increase the stability of the capsid and form the protrusions on the virion. A hypervariable region in P2 is thought to play an important role in receptor binding and immune reactivity.

Our VLPs are non-infectious and safe to use, while displaying native-like epitopes and glycosylation patterns. A study by Metz and colleagues, for example, showed that our VirtuE™-expressed dengue VLPs exhibit comparable epitopes to native viral particles. Our VLPs are suitable for a wide range of applications, including the development of in vitro diagnostic assays and vaccines. The highly repetitive structural patterns presented by VLPs also makes them ideal antigens for raising high-avidity antibodies.

For more information on each of our norovirus-like particles, click the buttons below or get in touch with a member of our team:

Norovirus GI.I VLP (Insect)

Norovirus GI.3 VLP (HEK293)

Norovirus GII.2 VLP (HEK293)

Norovirus GII.4 VLP (HEK293)

Norovirus GII.6 VLP (HEK293)

Norovirus GII.10 VLP (HEK293)

Norovirus GII.17 VLP (HEK293)

Norovirus GIX.1 VLP (HEK293)

Norovirus GII.3 VLP (Hu/GII.3/SW4/2012/TN)

See our Full Range

In addition to virus-like particles, we offer a range of genotype-specific primary antibodies:

See Our Full Range

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