Our Product Pipeline
We strive to provide the highest-quality reagents in support of infectious disease research. Some highlights of our current pipeline are shown below, but if you can’t see what you’re looking for, please contact us to find out if we already have it in development. If we don’t have what you need we may be able to develop it for you!
Our antigen pipeline reflects our specialism in the manufacture of infectious disease antigens to ensure retention of their native configuration. From initial research through to production scale-up we are focused on providing antigens which deliver real improvements to the sensitivity and specificity of serology-based IVDs, serve as effective immunogens and offer vital support in vaccine research. We specialise in preparing recombinant proteins using our in-house HEK293 mammalian cell expression system, which provides native post-translational modifications and correct folding. However, when appropriate, we also utilise E. coli and baculovirus-insect cell production systems. Our current R&D pipeline includes:
Design and Cloning
Undertaking an in silico review to design the optimal protein sequence and clone the sequence construct(s) into our optimised vectors.
Testing expression of a range of constructs in different platform systems to select the optimal conditions for this specific protein.
Purification and Scale-Up
Following expression we determine the best purification methods to maximise purity and yield, before scaling up to manufacturing quantities.
- African Swine Fever Virus pp62
- Japanese Encephalitis Virus-Like Particle
- Venezuelan Equine Encephalitis Virus E1 and E2
- Integrin Beta-3
- Marburg Virus-Like Particle
- West Nile Virus-Like Particle
- Yellow Fever Virus-Like Particle
- HIV gp140
- Influenza NA
If any of these antigens are of interest, get in touch to be included in our beta testing and to be first to partner using our unique antigens.
Our antibody pipeline reflects the continuing importance of developing highly specific and well characterised antibodies for use in infectious disease research and diagnosis. In particular, understanding the cross-reactivity profile of antibodies within closely related virus families is of especial importance. Our antibodies are developed against mammalian-expressed antigens, which are properly glycosylated and therefore representative of the native antigen that the antibodies must bind to. Our current antibody pipeline includes the following targets:
Antigens are selected and immunisation strategies are designed to maximise a specific and non-cross-reactive response.
Screening and Selection
Screening for reactivity to the target antigen and careful selection of antibodies that show desired cross-reactivity profiles using extensive antigen range.
Expansion and Characterisation
Preparation of larger quantities of antibodies for further characterisation in a range of applications, including functional analyses where possible.
- Crimean Congo Haemorrhagic Fever virus antibodies
- Nipah virus antibodies
- Lassa Fever virus antibodies
- Alphavirus (Chikungunya, Mayaro and O’nyong’nyong) antibodies
- Severe Fever with Thrombocytopenia Virus antibodies
If you would like to be among the first to test these reagents, do let us know and we can keep you up to date on their development.