Yellow Fever virus Envelope C-terminal His-tag (Insect Cells)

Yellow Fever virus Envelope produced in Sf21 insect cells and purified from culture supernatant of recombinant baculovirus infected cells.

PRODUCT DETAILS – Yellow Fever virus Envelope C-terminal His-tag (Insect Cells)

• Yellow Fever virus Envelope produced in Sf21 insect cells (Strain: 17D-204-USA vaccine, isolate HONG3).
• His-tag at C-terminal
• Recombinant Antigen
• NCBI Accession number: AAC35902.1
• Presented as liquid.

BACKGROUND

Yellow fever is an acute hemorrhagic disease caused by the Yellow Fever virus (YFV), which is a member of the Flaviviridae family of viruses. Clinical symptoms of YFV infection include fever, muscle pain, nausea and vomiting. In a small percentage of patients, the liver and kidneys are affected leading to jaundice, and in some cases death.

Yellow Ffever virus is endemic in tropical areas of Africa and Central/South America where the vector is widespread. In the virus’s sylvatic cycle, it is transmitted to non-human primates via mosquitoes of the Haemagogus and Sabethes genera, with occasional outbreaks of Yellow Fever in individuals working in forest areas. In the virus’s urban cycle, the Aedes aegypti mosquito is responsible for the transmission of Yellow Fever virus to humans in more populated areas.

In the late 1930’s a safe and effective attenuated vaccine was developed against the YFV, which confers long-term immunity (Norrby, E). The virulent wild-type Asibi strain of YFV was used to develop the YFV 17D vaccine, which is effective in immunising individuals at risk of YFV infection (WHO).

Diagnosis of yellow fever is complicated by the fact that early symptoms of the infection can be confused with other haemorrhagic diseases including Dengue. Differential diagnosis is therefore an important consideration in areas where other flaviviruses such as Dengue and Zika co-circulate.

REFERENCES

• Norrby E (2007). Yellow fever and Max Theiler: the only Nobel Prize for a virus vaccine. J Exp Med. 204 (12):2779
• World Health Organization; Yellow Fever