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Protein Expression Services

The Native Antigen Company have developed a proprietary mammalian cell protein production system, based on suspension-adapted HEK 293 cells. With a batch capacity of up to 80L, we are able to perform custom expression projects to produce recombinant proteins with human folding and glycosylation. This system is ideal for:

  • Complex folded and glycosylated proteins
  • Viral proteins
  • Cancer antigens

For projects where glycosylation is not required we offer expression in bacterial systems, and also have insect systems available so that we can choose the best system for your particular protein.

Developing your protein

Our protein expression services include:-

  • Consultation and strategy development with our Director of Research
  • DNA design and cloning
  • Vector and/or gene optimisation
  • Recombinant protein expression in mammalian cells, insect cells or bacteria
  • Protein purification

Protein expression can sometimes be more challenging than anticipated, and we have a repertoire of techniques to maximise the chances of success for each project. From our initial consultation we will develop a project plan designed to meet your requirements. All of our projects are defined with milestone steps, with progress being reported to you at each stage.

Typically a protein expression project will include a small scale feasibility experiment to assess protein expression before we scale up to purify larger amounts of material for you. in this way we can minimise your risk and overall project cost, whilst benefiting from our many years of experience in preparing a wide range of proteins.

“The service from the Native Antigen Company over an extended period for several protein expression projects has been exemplary.” – Peter Laing, CEO, Excivion Ltd
Thank you for the comprehensive answer. I am impressed of the data that you can provide because many companies have just the specification sheet to offer. Petri
“We are truly thankful for your most kind cooperation. It is a great pleasure working with you. Many thanks also for the file attached, so we can be sure about the exact sequences.” – Nina

Zika - development of mature VLPs

Preparation of mature Zika Virus-like particles for EM analysis, developed from our catalogue product for a specific customer requirement

Mutated Dengue Envelope proteins

Development of site-directed mutants of Dengue virus envelope proteins in support of vaccine R&D

Expression and purification of intracellular protein

Preparation of highly purified, bioactive protein, to support oncology clinical trials

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