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Protein Expression Services

The Native Antigen Company produces highly purified, concentrated proteins, for use in a range of research and diagnostic formats. Our senior research scientists hold over thirty years of protein expression experience and use state-of-the-art expression techniques. Our proprietary mammalian, HEK-293 cell line is used for recombinant protein expression to achieve human folding and glycosylation of proteins.

Developing Your Protein

Our mammalian cell line is ideal for the expression of:

  • Complex folded and glycosylated proteins
  • Viral proteins
  • Cancer antigens

For projects where glycosylation is not required, we offer expression in bacterial and insect systems, to ensure we can provide the optimal system for expression of your protein. Our production facilities are highly-scalable, with batch capacities of up to 80L.

The Native Antigen Company’s expression team has decades of experience in the field of recombinant protein production. Our development laboratories are staffed by a core team of PhD molecular biologists and development scientists who are able to execute projects as short as a few days, through to long-term programmes of a year or more. Our protein expression services include:

  • Consultation and strategy development with our Director of Research
  • DNA design and cloning
  • Vector and/or gene optimisation
  • Recombinant protein expression in mammalian, bacterial or insect cells
  • Protein purification

We understand that protein expression isn’t always straight-forward, so our team its repertoire of cutting-edge technologies and decades of experience in native and recombinant protein production to maximise the success of each project.

From our initial consultation, we develop a project plan to meet your specific requirements, with defined milestones and reporting at every step. We then, typically carry-out a small-scale protein expression test to assess project feasibility before scaling-up to purify larger amounts of your desired protein – minimising your project risk and overall cost.

“The service from the Native Antigen Company over an extended period for several protein expression projects has been exemplary.” – Peter Laing, CEO, Excivion Ltd
Thank you for the comprehensive answer. I am impressed of the data that you can provide because many companies have just the specification sheet to offer. Petri
“We are truly thankful for your most kind cooperation. It is a great pleasure working with you. Many thanks also for the file attached, so we can be sure about the exact sequences.” – Nina

Zika - development of mature VLPs

Preparation of mature Zika Virus-like particles for EM analysis, developed from our catalogue product for a specific customer requirement

Mutated Dengue Envelope proteins

Development of site-directed mutants of Dengue virus envelope proteins in support of vaccine R&D

Expression and purification of intracellular protein

Preparation of highly purified, bioactive protein, to support oncology clinical trials

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