Protein Expression Services
The Native Antigen Company have developed a proprietary mammalian cell protein production system, based on suspension-adapted HEK 293 cells. With a batch capacity of up to 80L, we are able to perform custom expression projects to produce recombinant proteins with human folding and glycosylation. This system is ideal for:
- Complex folded and glycosylated proteins
- Viral proteins
- Cancer antigens
For projects where glycosylation is not required we offer expression in bacterial systems, and also have insect systems available so that we can choose the best system for your particular protein.
Developing your protein
Our protein expression services include:-
- Consultation and strategy development with our Director of Research
- DNA design and cloning
- Vector and/or gene optimisation
- Recombinant protein expression in mammalian cells, insect cells or bacteria
- Protein purification
Protein expression can sometimes be more challenging than anticipated, and we have a repertoire of techniques to maximise the chances of success for each project. From our initial consultation we will develop a project plan designed to meet your requirements. All of our projects are defined with milestone steps, with progress being reported to you at each stage.
Typically a protein expression project will include a small scale feasibility experiment to assess protein expression before we scale up to purify larger amounts of material for you. in this way we can minimise your risk and overall project cost, whilst benefiting from our many years of experience in preparing a wide range of proteins.