The most crucial step for viruses during human infection is recognition and entry into host cells. For this to happen, specific proteins on the virus capsid interact with those on the host cells’ surface, through a ‘lock-and-key’-type mechanism that...
In the second of a 2-part series, we discuss how adenoviruses are being developed to treat cancer and some of the hurdles these platforms face from our own immune systems. Curing cancer is one of the biggest challenges of the 21st century. Our knowledge of cancer’s...
In the first of a 2-part series, we explore what makes adenoviruses so useful in gene therapy applications and how they are being developed as vectors for vaccines at the Jenner Institute in Oxford. Adenoviruses (ADVs) are non-enveloped icosahedral DNA viruses...