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Seasonal Influenza Vaccine Antigens

In February and September of each year, the World Health Organization (WHO) convenes with its network of advisors to decide on flu vaccine formulations for the northern and southern hemispheres, respectively. To support ongoing vaccine reformulation programmes, The Native Antigen Company develops season-specific antigens to support vaccine and diagnostic manufacturers.

Our Antigens

To support vaccine research and development, The Native Antigen Company has developed Haemagglutinin (HA) and Neuraminidase (NA) antigens for the WHO-recommended egg-based and recombinant vaccine strains. Available in bulk quantities, antigens can be used in a range of applications, including immunoassay development and as immunogens.

Expressed from our proprietary VirtuE™ HEK293 expression system, these antigens exhibit proper glycosylation and folding. Since the  2022/3 winter strains, our Haemagglutinin proteins have been offered as stabilized trimers, this structure is essential for the study of neutralizing antibodies in vaccine development.

 

From the 2023/4 winter strains, our Neuraminidase proteins are presented using an N-terminal domain which generates stable & enzymatically active NA tetramers. Neuraminidase protein in its native tetrameric conformation generates high levels of NA-reactive binding and inhibition antibodies. (Deng et al., 2021)  

We are keen to undertake production of novel strains /  mutants of Influenza HA & NA as a bespoke service, including in-vivo biotinylated antigens. Contact us to discuss your project now!

 

 

 

2024 -2025 Influenza Antigen For Northern Hemisphere Flu Season 

Species
Strain description
Antigen
GISAID No.
Product Code
 
Influenza A
 
 

A/Wisconsin/67/2022 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
EPI2224977
 
 
REC32096 >>>
 
 
A/Massachusetts/18/2022 (H3N2)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2096756
 
 
Enquire now >>>
 
 
A/Wisconsin/67/2022 (H1N1)pdm09-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2224978
 
 
REC32054 >>>
 
 
A/Victoria/4897/2022 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
EPI2319192
 
 
REC32092 >>>
 
 
A/Thailand/8/2022 (H3N2)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2236266
 
 
REC32101 >>>
 
 
A/Victoria/4897/2022 (H1N1)pdm09-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2319193
 
 
REC32052 >>>
 
 
A/Massachusetts/18/2022 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI2096755
 
 
Enquire now >>>
 
 
A/Thailand/8/2022 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI2236265
 
 
REC32104 >>>
 
 
Influenza B
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI1857129
 
 
REC32004 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI529344
 
 
REC32095 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
EPI529345
 
 
REC32054 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
EPI551297
 
 
REC32022 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI551296
 
 
REC32095 >>>
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
EPI1845793
 
 
REC32004 >>>
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1857130
 
 
REC32094 >>>
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1845794
 
 
REC32094 >>>
 

2024 Influenza Antigen For Southern Hemisphere Flu Season 

Species
Strain description
Antigen
GISAID No.
Product Code
 
Influenza A
 
 

Influenza A/Massachusetts/18/2022 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI2413618
 
 
REC32102 >>>
 
 
A/Massachusetts/18/2022 (H3N2)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2413620
 
 
REC32100 >>>
 
 
A/Thailand/8/2022 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI2236265
 
 
REC32104 >>>
 
 
A/Thailand/8/2022 (H3N2)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2236266
 
 
REC32101 >>>
 
 
A/Victoria/4897/2022 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
EPI2319192
 
 
REC32092 >>>
 
 
A/Victoria/4897/2022 (H1N1)pdm09-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2319193
 
 
REC32052 >>>
 
 
A/Wisconsin/67/2022 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
EPI2224977
 
 
REC32096 >>>
 
 
A/Wisconsin/67/2022 (H1N1)pdm09-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2224978
 
 
REC32054 >>>
 
 
Influenza B
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1845794
 
 
REC32094 >>>
 
 
B/Austria/1359417/2021(B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1857130
 
 
REC32094 >>>
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1857129
 
 
REC32004 >>>
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1845793
 
 
REC32004 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI529344
 
 
REC32095 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI551296
 
 
REC32095 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
EPI529345
 
 
REC32054 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
EPI551297
 
 
REC32022 >>>
 

H5N1 Strains

Species
Strain description
Protein
GISAID No.
Product Code
 
Influenza A
 
 
A/chicken/Scotland/054477/2021
 
 
Nucleoprotein (NP)
 
 
EPI1963385
 
 
REC32055 >>>
 
 
A/Greylag_goose/England/054503/2021
 
 
Nucleoprotein (NP)
 
 
EPI1963898
 
 
REC32056 >>>
 
 
A/Greylag_goose/Scotland/024915/2022
 
 
Nucleoprotein (NP)
 
 
EPI2076366
 
 
REC32057 >>>
 
 
AA/Duck/Egypt/AR526/2017
 
 
Nucleoprotein (NP)
 
 
EPI1420358
 
 
REC32058 >>>
 
 
A/Cambodia/NPH230032/2023
 
 
Nucleoprotein (NP)
 
 
EPI2419703
 
 
REC32059 >>>
 
 
A/Greylag_goose/Scotland/024915/2022
 
 
Hemagglutinin (HA)
 
 
EPI2076373
 
 
REC32060 >>>
 
 
A/Greylag_goose/Scotland/024915/2022
 
 
Neuraminidase (NA)
 
 
EPI2076372
 
 
REC32061 >>>
 

2023-2024 Influenza Antigens for Northern Hemisphere Flu Season

Species
Strain description
Antigen
GISAID No.
Product Code
 
Influenza A
 
 
A/Victoria/4897/2022 (H1N1)pdm09-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2319193
 
 
REC32052 >>>
 
 
A/Victoria/4897/2022 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
EPI2319192
 
 
REC32051 >>>
 
 
A/Darwin/9/2021 (H3N2)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI1859996
 
 
REC32002 >>>
 
 
A/Darwin/9/2021 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1859995
 
 
REC32003 >>>
 
 
A/Wisconsin/67/2022 (H1N1)pdm09-like virus
 
 
Hemagglutinin (HA)
 
 
EPI2224978
 
 
REC32054 >>>
 
 
A/Wisconsin/67/2022 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
EPI2224977
 
 
REC32053 >>>
 
 
A/Darwin/6/2021 (H3N2)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI1859992
 
 
REC32020 >>>
 
 
A/Darwin/6/2021 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1859991
 
 
REC32021 >>>
 
 
Influenza B
 
 
B/Austria/1359417/2021-(B/Victoria lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
EPI1868375
 
 
REC32004 >>>
 
 
B/Austria/1359417/2021-(B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1868374
 
 
REC32005 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
EPI551297
 
 
REC32022 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI529344
 
 
REC31955 >>>
 

2023 Southern Hemisphere Flu Season Antigens

Species
Strain/Subtype
Antigen
GISAID No.
Product Code
 
Influenza A
 
 
A/Darwin/6/2021 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1885401
 
 
REC32021 >>>
 
 
A/Darwin/6/2021 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1885402
 
 
REC32037 >>>
 
 
A/Darwin/9/2021 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1859995
 
 
REC32003 >>>
 
 
A/Darwin/9/2021 (H3N2)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI1859996
 
 
REC32002 >>>
 
 
A/Sydney/5/2021 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
EPI1942221
 
 
REC32040 >>>
 
 
A/Sydney/5/2021 (H1N1)pdm09-like virus
 
 
Hemagglutinin (HA)
 
 
EPI1942222
 
 
REC32038 >>>
 
 
A/Wisconsin/588/2019 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
EPI1957292
 
 
REC32040 >>>
 
 
A/Sydney/5/2021 (H1N1)pdm09-like virus
 
 
Hemagglutinin (HA)
 
 
EPI1957293
 
 
REC32039 >>>
 
 
Influenza B
 
 
B/Austria/1359417/2021
 
 
Haemagglutinin (HA)
 
 
EPI1857129
 
 
REC32004 >>>
 
 
B/Austria/1359417/2021
 
 
Neuraminidase (NA)
 
 
EPI1857130
 
 
REC32005 >>>
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
EPI1845793
 
 
REC32004 >>>
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1845794
 
 
REC32005 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1857129
 
 
REC31955 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI529345
 
 
REC32022 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Neuraminidase (NA)
 
 
EPI551296
 
 
REC31955 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Hemagglutinin (HA)
 
 
EPI551297
 
 
REC32022 >>>
 
 
A/Darwin/6/2021 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
EPI1885401
 
 
REC32021 >>>
 
2022 Northern Hemisphere Flu Season Antigens
Species
Strain/Subtype
Antigen
Product Code
 
Influenza A
 
 
A/Victoria/2570/2019 (H1N1)pdm09-like virus
 
 
Haemagglutinin (HA)
 
 
REC32023 >>>
 
 
A/Victoria/2570/2019 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
REC31950 >>>
 
 
A/Darwin/6/2021 (H3N2)-like virus
 
 
Haemagglutinin (HA)
 
 
REC32020 >>>
 
 
A/Darwin/6/2021 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
REC32021 >>>
 
 
A/Darwin/9/2021 (H3N2)-like virus
 
 
Haemagglutinin (HA)
 
 
REC32002 >>>
 
 
A/Darwin/9/2021 (H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
REC32003 >>>
 
 
A/Wisconsin/588/2019 (H1N1)pdm09-like virus
 
 
Haemagglutinin (HA)
 
 
REC32000 >>>
 
 
A/Wisconsin/588/2019 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
REC32025 >>>
 
 
Influenza B
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
REC32004 >>>
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
REC32005 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
REC32022 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
 
 
Neuraminidase (NA)
 
 
REC31955 >>>
 

2022 Southern Hemisphere Flu Season Antigens

Species
Strain/Subtype
Antigen
Product Code
 
Influenza A
 
 
A/Wisconsin/588/2019 (H1N1)pdm09-like virus
 
 
Haemagglutinin (HA)
 
 
REC32000 >>>
 
 
A/Wisconsin/588/2019 (H1N1)pdm09-like virus
 
 
Neuraminidase (NA)
 
 
REC32001 >>>
 
 
A/Darwin/9/2021(H3N2)-like virus
 
 
Haemagglutinin (HA)
 
 
REC32002 >>>
 
 
A/Darwin/9/2021(H3N2)-like virus
 
 
Neuraminidase (NA)
 
 
REC32003 >>>
 
 
Influenza B
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
REC32004 >>>
 
 
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
 
 
Neuraminidase (NA)
 
 
REC32005 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata Lineage)-like virus
 
 
Haemagglutinin (HA)
 
 
REC31954 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata Lineage)-like virus
 
 
Neuraminidase (NA)
 
 
REC31955 >>>
 

2021-2022 Northern Hemisphere Flu Season Antigens

Species
Strain/Subtype
Antigen
Product Code
 
Influenza A
 
 
A/Victoria/2570/2019 (H1N1)pdm09-Like
 
 
Haemagglutinin (HA)
 
 
REC31949 >>>
 
 
A/Victoria/2570/2019 (H1N1)pdm09-Like
 
 
Neuraminidase (NA)
 
 
REC31950 >>>
 
 
A/Cambodia/e0826360/2020 (H3N2)-Like
 
 
Haemagglutinin (HA)
 
 
REC31951 >>>
 
 
A/Cambodia/e0826360/2020 (H3N2)-Like
 
 
Neuraminidase (NA)
 
 
REC31952 >>>
 
 
Influenza B
 
 
B/Washington/02/2019 (B/Victoria lineage)-Like
 
 
Haemagglutinin (HA)
 
 
REC31888 >>>
 
 
B/Washington/02/2019 (B/Victoria lineage)-Like
 
 
Neuraminidase (NA)
 
 
REC31889 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata Lineage)-Like
 
 
Haemagglutinin (HA)
 
 
REC31954 >>>
 
 
B/Phuket/3073/2013 (B/Yamagata Lineage)-Like
 
 
Neuraminidase (NA)
 
 
REC31955 >>>
 

Our Influenza Products

We also offer an extensive range of recombinant HA/NA antigens, native cell lysates and species-specific monoclonal antibodies for established strains.

Our Influenza Services

To support influenza vaccine development, The Native Antigen Company also offers custom services to rapidly develop panels of high quality influenza antigens.

For a bespoke proposal and consultation, please get in touch using the form below

Would you like to be kept informed of the latest news and innovations from the infectious disease community? Please let us know if you would like us to contact you or not by selecting one of the options below.

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