Seasonal Influenza Vaccine Antigens

In February and September of each year, the World Health Organization (WHO) convenes with its network of advisors to decide on flu vaccine formulations for the northern and southern hemispheres, respectively. To support ongoing vaccine reformulation programmes, The Native Antigen Company develops season-specific antigens to support vaccine and diagnostic manufacturers.

Our Antigens

To support vaccine research and development, The Native Antigen Company has developed Haemagglutinin (HA) and Neuraminidase (NA) antigens for the WHO-recommended egg-based and recombinant vaccine strains. Available in bulk quantities, antigens can be used in a range of applications, including immunoassay development and as immunogens.

Expressed from our proprietary VirtuE™ HEK293 expression system, these antigens exhibit proper glycosylation and folding. Since the 2022/3 winter strains, our Haemagglutinin proteins have been offered as stabilized trimers, this structure is essential for the study of neutralizing antibodies in vaccine development.

From the 2023/4 winter strains, our Neuraminidase proteins are presented using an N-terminal domain which generates stable & enzymatically active NA tetramers. Neuraminidase protein in its native tetrameric conformation generates high levels of NA-reactive binding and inhibition antibodies. (Deng et al., 2021)

We are keen to undertake production of novel strains / mutants of Influenza HA & NA as a bespoke service, including in-vivo biotinylated antigens. Contact us to discuss your project now!

2024 -2025 Influenza Antigen For Northern Hemisphere Flu Season

Species	Strain description	Antigen	GISAID No.	Product Code
Influenza A	A/Wisconsin/67/2022 (H1N1)pdm09-like virus	Neuraminidase (NA)	EPI2224977	REC32096 >>>
	A/Massachusetts/18/2022 (H3N2)-like virus	Hemagglutinin (HA)	EPI2096756	Enquire now >>>
	A/Wisconsin/67/2022 (H1N1)pdm09-like virus	Hemagglutinin (HA)	EPI2224978	REC32054 >>>
	A/Victoria/4897/2022 (H1N1)pdm09-like virus	Neuraminidase (NA)	EPI2319192	REC32092 >>>
	A/Thailand/8/2022 (H3N2)-like virus	Hemagglutinin (HA)	EPI2236266	REC32101 >>>
	A/Victoria/4897/2022 (H1N1)pdm09-like virus	Hemagglutinin (HA)	EPI2319193	REC32052 >>>
	A/Massachusetts/18/2022 (H3N2)-like virus	Neuraminidase (NA)	EPI2096755	Enquire now >>>
	A/Thailand/8/2022 (H3N2)-like virus	Neuraminidase (NA)	EPI2236265	REC32104 >>>
Influenza B	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Hemagglutinin (HA)	EPI1857129	REC32004 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Neuraminidase (NA)	EPI529344	REC32095 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Haemagglutinin (HA)	EPI529345	REC32054 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Haemagglutinin (HA)	EPI551297	REC32022 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Neuraminidase (NA)	EPI551296	REC32095 >>>
	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Haemagglutinin (HA)	EPI1845793	REC32004 >>>
	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Neuraminidase (NA)	EPI1857130	REC32094 >>>
	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Neuraminidase (NA)	EPI1845794	REC32094 >>>

2024 Influenza Antigen For Southern Hemisphere Flu Season

Species	Strain description	Antigen	GISAID No.	Product Code
Influenza A	Influenza A/Massachusetts/18/2022 (H3N2)-like virus	Neuraminidase (NA)	EPI2413618	REC32102 >>>
	A/Massachusetts/18/2022 (H3N2)-like virus	Hemagglutinin (HA)	EPI2413620	REC32100 >>>
	A/Thailand/8/2022 (H3N2)-like virus	Neuraminidase (NA)	EPI2236265	REC32104 >>>
	A/Thailand/8/2022 (H3N2)-like virus	Hemagglutinin (HA)	EPI2236266	REC32101 >>>
	A/Victoria/4897/2022 (H1N1)pdm09-like virus	Neuraminidase (NA)	EPI2319192	REC32092 >>>
	A/Victoria/4897/2022 (H1N1)pdm09-like virus	Hemagglutinin (HA)	EPI2319193	REC32052 >>>
	A/Wisconsin/67/2022 (H1N1)pdm09-like virus	Neuraminidase (NA)	EPI2224977	REC32096 >>>
	A/Wisconsin/67/2022 (H1N1)pdm09-like virus	Hemagglutinin (HA)	EPI2224978	REC32054 >>>
Influenza B	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Neuraminidase (NA)	EPI1845794	REC32094 >>>
	B/Austria/1359417/2021(B/Victoria lineage)-like virus	Neuraminidase (NA)	EPI1857130	REC32094 >>>
	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Neuraminidase (NA)	EPI1857129	REC32004 >>>
	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Neuraminidase (NA)	EPI1845793	REC32004 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Neuraminidase (NA)	EPI529344	REC32095 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Neuraminidase (NA)	EPI551296	REC32095 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Haemagglutinin (HA)	EPI529345	REC32054 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Haemagglutinin (HA)	EPI551297	REC32022 >>>

H5N1 Strains

Species	Strain description	Protein	GISAID No.	Product Code
Influenza A	A/chicken/Scotland/054477/2021	Nucleoprotein (NP)	EPI1963385	REC32055 >>>
	A/Greylag_goose/England/054503/2021	Nucleoprotein (NP)	EPI1963898	REC32056 >>>
	A/Greylag_goose/Scotland/024915/2022	Nucleoprotein (NP)	EPI2076366	REC32057 >>>
	AA/Duck/Egypt/AR526/2017	Nucleoprotein (NP)	EPI1420358	REC32058 >>>
	A/Cambodia/NPH230032/2023	Nucleoprotein (NP)	EPI2419703	REC32059 >>>
	A/Greylag_goose/Scotland/024915/2022	Hemagglutinin (HA)	EPI2076373	REC32060 >>>
	A/Greylag_goose/Scotland/024915/2022	Neuraminidase (NA)	EPI2076372	REC32061 >>>

2023-2024 Influenza Antigens for Northern Hemisphere Flu Season

Species	Strain description	Antigen	GISAID No.	Product Code
Influenza A	A/Victoria/4897/2022 (H1N1)pdm09-like virus	Hemagglutinin (HA)	EPI2319193	REC32052 >>>
	A/Victoria/4897/2022 (H1N1)pdm09-like virus	Neuraminidase (NA)	EPI2319192	REC32051 >>>
	A/Darwin/9/2021 (H3N2)-like virus	Hemagglutinin (HA)	EPI1859996	REC32002 >>>
	A/Darwin/9/2021 (H3N2)-like virus	Neuraminidase (NA)	EPI1859995	REC32003 >>>
	A/Wisconsin/67/2022 (H1N1)pdm09-like virus	Hemagglutinin (HA)	EPI2224978	REC32054 >>>
	A/Wisconsin/67/2022 (H1N1)pdm09-like virus	Neuraminidase (NA)	EPI2224977	REC32053 >>>
	A/Darwin/6/2021 (H3N2)-like virus	Hemagglutinin (HA)	EPI1859992	REC32020 >>>
	A/Darwin/6/2021 (H3N2)-like virus	Neuraminidase (NA)	EPI1859991	REC32021 >>>
Influenza B	B/Austria/1359417/2021-(B/Victoria lineage)-like virus	Haemagglutinin (HA)	EPI1868375	REC32004 >>>
	B/Austria/1359417/2021-(B/Victoria lineage)-like virus	Neuraminidase (NA)	EPI1868374	REC32005 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Haemagglutinin (HA)	EPI551297	REC32022 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Neuraminidase (NA)	EPI529344	REC31955 >>>

2023 Southern Hemisphere Flu Season Antigens

Species	Strain/Subtype	Antigen	GISAID No.	Product Code
Influenza A	A/Darwin/6/2021 (H3N2)-like virus	Neuraminidase (NA)	EPI1885401	REC32021 >>>
	A/Darwin/6/2021 (H3N2)-like virus	Neuraminidase (NA)	EPI1885402	REC32037 >>>
	A/Darwin/9/2021 (H3N2)-like virus	Neuraminidase (NA)	EPI1859995	REC32003 >>>
	A/Darwin/9/2021 (H3N2)-like virus	Hemagglutinin (HA)	EPI1859996	REC32002 >>>
	A/Sydney/5/2021 (H1N1)pdm09-like virus	Neuraminidase (NA)	EPI1942221	REC32040 >>>
	A/Sydney/5/2021 (H1N1)pdm09-like virus	Hemagglutinin (HA)	EPI1942222	REC32038 >>>
	A/Wisconsin/588/2019 (H1N1)pdm09-like virus	Neuraminidase (NA)	EPI1957292	REC32040 >>>
	A/Sydney/5/2021 (H1N1)pdm09-like virus	Hemagglutinin (HA)	EPI1957293	REC32039 >>>
Influenza B	B/Austria/1359417/2021	Haemagglutinin (HA)	EPI1857129	REC32004 >>>
	B/Austria/1359417/2021	Neuraminidase (NA)	EPI1857130	REC32005 >>>
	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Haemagglutinin (HA)	EPI1845793	REC32004 >>>
	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Neuraminidase (NA)	EPI1845794	REC32005 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Neuraminidase (NA)	EPI1857129	REC31955 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Hemagglutinin (HA)	EPI529345	REC32022 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Neuraminidase (NA)	EPI551296	REC31955 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Hemagglutinin (HA)	EPI551297	REC32022 >>>
	A/Darwin/6/2021 (H3N2)-like virus	Neuraminidase (NA)	EPI1885401	REC32021 >>>

2022 Northern Hemisphere Flu Season Antigens

Species	Strain/Subtype	Antigen	Product Code
Influenza A	A/Victoria/2570/2019 (H1N1)pdm09-like virus	Haemagglutinin (HA)	REC32023 >>>
	A/Victoria/2570/2019 (H1N1)pdm09-like virus	Neuraminidase (NA)	REC31950 >>>
	A/Darwin/6/2021 (H3N2)-like virus	Haemagglutinin (HA)	REC32020 >>>
	A/Darwin/6/2021 (H3N2)-like virus	Neuraminidase (NA)	REC32021 >>>
	A/Darwin/9/2021 (H3N2)-like virus	Haemagglutinin (HA)	REC32002 >>>
	A/Darwin/9/2021 (H3N2)-like virus	Neuraminidase (NA)	REC32003 >>>
	A/Wisconsin/588/2019 (H1N1)pdm09-like virus	Haemagglutinin (HA)	REC32000 >>>
	A/Wisconsin/588/2019 (H1N1)pdm09-like virus	Neuraminidase (NA)	REC32025 >>>
Influenza B	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Haemagglutinin (HA)	REC32004 >>>
	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Neuraminidase (NA)	REC32005 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Haemagglutinin (HA)	REC32022 >>>
	B/Phuket/3073/2013 (B/Yamagata lineage)-like virus	Neuraminidase (NA)	REC31955 >>>

2022 Southern Hemisphere Flu Season Antigens

Species	Strain/Subtype	Antigen	Product Code
Influenza A	A/Wisconsin/588/2019 (H1N1)pdm09-like virus	Haemagglutinin (HA)	REC32000 >>>
	A/Wisconsin/588/2019 (H1N1)pdm09-like virus	Neuraminidase (NA)	REC32001 >>>
	A/Darwin/9/2021(H3N2)-like virus	Haemagglutinin (HA)	REC32002 >>>
	A/Darwin/9/2021(H3N2)-like virus	Neuraminidase (NA)	REC32003 >>>
Influenza B	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Haemagglutinin (HA)	REC32004 >>>
	B/Austria/1359417/2021 (B/Victoria lineage)-like virus	Neuraminidase (NA)	REC32005 >>>
	B/Phuket/3073/2013 (B/Yamagata Lineage)-like virus	Haemagglutinin (HA)	REC31954 >>>
	B/Phuket/3073/2013 (B/Yamagata Lineage)-like virus	Neuraminidase (NA)	REC31955 >>>

2021-2022 Northern Hemisphere Flu Season Antigens

Species	Strain/Subtype	Antigen	Product Code
Influenza A	A/Victoria/2570/2019 (H1N1)pdm09-Like	Haemagglutinin (HA)	REC31949 >>>
	A/Victoria/2570/2019 (H1N1)pdm09-Like	Neuraminidase (NA)	REC31950 >>>
	A/Cambodia/e0826360/2020 (H3N2)-Like	Haemagglutinin (HA)	REC31951 >>>
	A/Cambodia/e0826360/2020 (H3N2)-Like	Neuraminidase (NA)	REC31952 >>>
Influenza B	B/Washington/02/2019 (B/Victoria lineage)-Like	Haemagglutinin (HA)	REC31888 >>>
	B/Washington/02/2019 (B/Victoria lineage)-Like	Neuraminidase (NA)	REC31889 >>>
	B/Phuket/3073/2013 (B/Yamagata Lineage)-Like	Haemagglutinin (HA)	REC31954 >>>
	B/Phuket/3073/2013 (B/Yamagata Lineage)-Like	Neuraminidase (NA)	REC31955 >>>

Our Influenza Products

We also offer an extensive range of recombinant HA/NA antigens, native cell lysates and species-specific monoclonal antibodies for established strains.

See Our Full Influenza Range

Our Influenza Services

To support influenza vaccine development, The Native Antigen Company also offers custom services to rapidly develop panels of high quality influenza antigens.

For a bespoke proposal and consultation, please get in touch using the form below

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HITTING A MOVING TARGET

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In this blog, we explain how seasonal and pandemic influenza vaccines are developed, manufactured and validated, and introduce our contract services for the rapid development of custom influenza reagents.The Influenza Viruses: A Quick Recap The influenza viruses are...