Mouse anti Zika virus envelope protein Zika virus NS1 protein Zika Virus VLP Zika Virus Envelope Protein purified zika virus lysate zika virus vero cell lysate Mouse anti Zika virus NS1 antibody Mouse anti Flavivirus Envelope protein antibody (4G2) Human IgG1 Anti Zika Virus NS1 monoclonal antibody Human IgM Anti Zika Virus NS1 monoclonal antibody

Mouse anti Flavivirus Envelope protein antibody (4G2)

Product TypeMonoclonal antibody
Purity>95% pure by SDS-PAGE
Strainn/a
PresentationLiquid
Protein Conc.0.5 - 1mg/ml
Product CodeAbFLAVENV-4G2
Vial Size100μg

$348.75

Clear

Product Description

Mouse anti Flavivirus Envelope protein antibody (4G2)

Mouse anti Flavivirus Envelope protein antibody (4G2) binds to a conserved epitope on the E protein of the flavivirus family.  It has been shown to recognise Dengue virus, West Nile virus, Japanese Encephalitis virus and Zika Virus (Aubry et al. 2016). It binds to the fusion loop at the extremity of domain II of E protein and prevents syncytia formation (Summers, 1989). The epitope is highly conserved amongst flaviviridae and has been functionally analyzed in detail by Crill and Chang (2004)

This antibody has been tested on Dengue VLPs produced by the Native Antigen Company, and shown to bind effectively to these in ELISA assay.  The antibody has been shown to work in Western blotting, neutralisation and flow cytometric applications.

References

Nawa, M. et al (2001) Development of dengue IgM-capture enzyme-linked immunosorbent assay with higher sensitivity using monoclonal detection antibody.  J. Virol Methods 92:65-70.

Aubry, M. et al (2016) Inactivation of Zika virus in plasma with amotosalen and ultraviolet A illumination.  Transfusion 56:33-40

Summers, P. et al (1989) Flaviviruses can mediate fusion from without in Aedes albopictus mosquito cell cultures.  Virus Res.  12:383-392

Crill, W. and Chang, G. (2004)  Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes.  J. Virol. 78:13975 – 86

For further details please see the product datasheet here.

Additional Information

Vial Size

100μg

Menu