GOAT ANTI-RENIBACTERIUM SALMONINARUM ANTIBODY

Affinity purified polyclonal antibody to Renibacterium salmoninarum made in goat (BacTrace®). Isolated from a serum pool of goats immunized with heat killed whole cells of R. salmonarium. The antibody is highly specific for R. salmoninarum. Cross reactivity to other fish pathogens and normal fish flora has been minimized through extensive adsorption. Each lot is tested to assure specificity and lot-to-lot consistency using an in-house ELISA assay.

PRODUCT DETAILS – GOAT ANTI-RENIBACTERIUM SALMONINARUM SPECIES ANTIBODY

• Part of the BacTrace® range of antigens and antibodies.
• Affinity purified antibody made in goat.
• Isolated from a pool of serum from goats immunized with heat-killed whole cells of Renibacterium.
• This product is designed to react specifically with Renibacterium salmoninarum. Product is tested via ELISA techniques as applicable. Cross reactivity to other fish pathogens and normal fish flora has been minimized through extensive adsorption.
• Product is in lyophilized form.
• Each lot is tested to assure specificity and lot-to-lot consistency using an in-house ELISA assay.

BACKGROUND

Renibacterium salmoninarum is the causative agent of bacterial kidney disease (BKD), an important disease, particularly in salmonid fish worldwide. The bacteria can be transmitted both vertically and horizontally. Wild and cultured salmonids can be affected by R. salmoninarum at all stages of life and it has a serious impact on the salmonid industry. R. salmoninarum has been associated with mortalities as high as 80% in Pacific salmon (Oncorhynchus spp.) and 40% in Atlantic salmon (Salmo salar). In some extreme cases, daily mortality rates as high as 5% have been reported, mostly in juvenile salmons 6 to 12 months old and pre-spawning adults. Control of the disease is difficult; the presence of asymptomatic carriers complicates the eradication of the disease, as does the ability of the bacterium to gain entrance inside the eggs. Bacterin-killed vaccines have proven to be of doubtful efficacy in controlling the disease, and even more recent application of a virulent environmental relative of R. salmoninarum is of limited efficacy. Treatment by antibiotics such as erythromycin, azithromycin and enrofloxacin can be effective but it is slow and requires prolonged treatment. Antibiotic-resistant strains have also been reported (Delghandi et al., 2020).

REFERENCES

• Delghandi MR, El-Matbouli M, Menanteau-Ledouble S. Renibacterium salmoninarum-The Causative Agent of Bacterial Kidney Disease in Salmonid Fish. Pathogens. 2020;9(10):845. Published 2020 Oct 15. doi:10.3390/pathogens9100845.