MXRA8 Recombinant Protein
Human MXRA8, also known as DICAM, is a transmembrane adhesion protein that is expressed on the endothelium of many tissues (1).
It has recently been shown that MXRA8 acts as a viral entry receptor for alphaviruses, including Chikungunya virus, Mayaro virus and O’nyong’nyong virus. Blocking this interaction with antibodies has been shown to reduce the severity of infection with these viruses in mouse models, and therefore MXRA8 is now receiving attention as a possible therapeutic target.
We are pleased to make available highly purified recombinant MXRA8 produced in our mammalian expression system using HEK293 cells. Alongside our recombinant alphavirus proteins, this reagent offers an excellent model for studying alphavirus infection. We have demonstrated that recombinant MXRA8 binds to our recombinant Chikungunya Virus-like particles, mimicking the natural interaction during viral infection, and therefore providing a simple to use in vitro model to assess potential therapeutic molecules that block the virus receptor interaction.
MRXA8 is available in two different forms to provide maximum flexibility to researchers. We offer this version with a mouse Fc tag alongside a HIS tagged protein.
References
- Jung, Y.K. et al. (2008) J. Cell Physiol. 216:603.
- Zhang, R. et al (2018) Nature 557:570-574
