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SARS-CoV-2 Spike S1 Mutants

The Native Antigen Company now offers a range of five Spike S1 mutants, based on common SARS-CoV-2 sequences, all of which include the D614G mutation. These mutants can be used to investigate differences in binding affinity to ACE2 and anti-Spike antibodies in basic research or the development of SARS-CoV-2-specific countermeasures. Click here to see our full coronavirus range.

SARS-CoV-2 Whole Spike Trimer with Mutants Labelled

3D structure of Spike trimer embedded in lipid bilayer. 
Mutants are shown green and labelled accordingly.

Custom Services

The Native Antigen Company also offers a range of custom services, including the development of bespoke SARS-CoV-2 protein mutants via site-directed mutagenesis. In addition, we also offer antibody generation and immunoassay development services to provide further support to your research.

To discuss our custom service offering, click the link below:

Our Coronavirus Range

The Native Antigen Company offers an extensive and growing range of SARS-CoV-2 antigens, suitable for a variety of applications, including assay development, vaccine screening, neutralisation testing, immunofluorescence, surface plasmon resonance and academic research.

We also offer a variety of monoclonal and polyclonal coronavirus antibodies for use in immunoassays, Western blots, neutralisation assays, surface plasmon resonance and X-ray crystallography. Anti-SARS-CoV-2 Spike (CR3022) IgG antibodies are available in both humanised and rabbit-derived forms, in addition to a humanised IgM. An anti-Spike IgA monoclonal with affinity for the SARS-CoV-2/SARS-CoV RBD is also available.

The Native Antigen Company also offers an extensive and growing range antigens for SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E and HCoV-HKU1. These antigens are suitable for a variety of applications, including assay development, vaccine screening, neutralisation testing, immunofluorescence, surface plasmon resonance and academic research.