SHIGELLA SPECIES CELLS, HEAT-INACTIVATED

Heat-killed Shigella species cells in dextran solution. Antigen is intended for use as a positive control in immunoassay development for Shigella detection.

PRODUCT DETAILS – SHIGELLA SPECIES CELLS, HEAT-INACTIVATED

• Heat-killed Shigella boydii, Shigella flexneri, and Shigella dysenteriae cells in dextran solution.
• Part of the BacTrace® range of antigens and antibodies.
• This product is ideally suited for use as a positive control in immunoassays designed for the detection of Shigella. It provides verification of the functionality of the assay system.
• Product is considered non-hazardous as defined by The Hazard Communication Standard (29 CFR 1910.1200).

BACKGROUND

Shigella is the primary agent of bacillary dysentery, also referred to as shigellosis. Shigellae are Gram-negative, non-motile rods that are transmitted by the direct faecal–oral route. There are four species within the genus Shigella: Shigella dysenteriae, Shigella flexneri, Shigella boydii, and Shigella sonnei. These four species are also designated as subgroups A, B, C, and D, respectively. With the exception of S. sonnei, each species is made up of multiple serovars. S. dysenteriae has 15 serovars, S. flexneri has six serovars (with one to five possessing subtypes a and b), and S. boydii has 20 serovars. Shigella species cause an estimated 167 million episodes of diarrhea worldwide and over a million deaths. S. sonnei is predominantly responsible for dysentery in developed countries but is replacing S. flexneri as a problem in the developing world. Foodborne outbreaks are often linked to salad items contaminated at the country of origin or by the food handler. The global spread of Shigella clones or the emergence of new S. flexneri serotypes is associated with multidrug resistance. As the antibiotic-resistant Shigella strains are increasing worldwide, they severely limit treatment options (Aslam & Okafor, 2021).

REFERENCES

• Aslam A, Okafor CN. Shigella. 2021 Aug 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 29493962.