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Omicron Antigens Now Available

The Native Antigen Company now offers whole Spike, S1 and RBD antigens for the SARS-CoV-2 Omicron (B.1.1.529) variant. Produced from our VirtuE expression system, our Spike antigens exhibit full glycosylation and proper folding, ideal for developing high quality immunoassays and raising highly specific antibodies.

About the Omicron Variant

The novel B.1.1.529 SARS-CoV-2 variant was designated Omicron on the 26th November, following its increasing prevalence in South Africa. Harbouring more than 30 mutations in its Spike gene, the principal concerns surround Omicron’s infectivity, virulence and ability to circumvent vaccine protection.

To understand the threat that Omicron poses, researchers have begun closely tracking its spread and investigating all facets of its biology. The nature of research carried out so far follows that of other variants, including analysis of epidemiological data, in vitro binding studies and computational modelling. So far, little is known about the new variant. However, parallels with other variants and emerging data are beginning to give an indication.

Omicron shares multiple mutations with other SARS-CoV-2 variants that have been shown to mediate increased transmissibility and antibody escape, while the effects of many new mutations are yet unknown. Accumulating epidemiological data also supports increased transmissibility over Delta, which Omicron may displace in time. The increases in transmissibility are not yet clear at the mutation-level. However, data from South Africa suggests that higher transmission is in part driven by the ability for Omicron to evade a greater degree of natural and vaccine-induced immunity, especially in younger age groups.

Our Antigens

The Native Antigen Company now offers three Spike antigens for the SARS-CoV-2 Omicron variant: 

Whole Spike Antigen (REC32008)

Our trimeric whole Spike antigen is stabilised as a pre-fusion trimer via six amino acid (HexaPro) changes in the S2 subunit, in addition to a GSAS mutation in the furin cleavage site and a His-Strep-tag at the C-terminus for ease of purification.

Spike S1 Antigen (REC32006)

Our Spike S1 antigen includes residues 1-674 of the full Spike sequence and a C-terminal sheep Fc-tag for ease of purification.

Spike RBD Antigen

Our Spike receptor-binding domain (RBD) antigen includes residues 319-542 of the full Spike sequence and a C-terminal His-tag for ease of purification.

Our antigens are available in 100μg and 500μg sizes, as well as bulk supply of multiple grams.

Produced from our VirtuE expression system, our Spike antigens exhibit full glycosylation and proper folding, ideal for developing high quality immunoassays and raising highly specific antibodies.

For more information on these products, get in touch with a member of our team.

Red Spike Trimer, White Glycans

Antigen
Mutations in Reference to Wuhan-Hu-1 Wild-Type
Whole Spike
(REC32008)
 
A67V
Δ69-70
T95I
G142D
Δ143-145
Δ211
L212I
ins214EPE
G339D
S371L
S373P
S375F
K417N
N440K
G446S
S477N
T478K
E484A
Q493R
G496S
Q498R
N501Y
Y505H
T547K
D614G
H655Y
N679K
P681H
N764K
D796Y
N856K
Q954H
N969K
L981F
 
 
Spike S1
(REC32006)
 
 
A67V
Δ69-70
T95I
G142D
Δ143-145
Δ211
L212I
ins214EPE
G339D
S371L
S373P
S375F
K417N
N440K
G446S
S477N
T478K
E484A
Q493R
G496S
Q498R
N501Y
Y505H
T547K
D614G
H655Y
N679K
P681H
N764K
D796Y
 
 
Spike RBD
(REC32007)
 
 
G339D
S371L
S373P
S375F
K417N
N440K
G446S
S477N
T478K
E484A
Q493R
G496S
Q498R
N501Y
Y505H
 

Get in touch

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