The Native Antigen Company is part of LGC Clinical Diagnostics - Learn More

0 Items
Select Page

 New tools for HIV diagnosis: Discover our gp140 portfolio! 

Our solutions to the HIV assay manufacture challenges

The viral entry receptor for HIV-1 and HIV-2 is the Envelope protein gp160, a transmembrane glycoprotein featuring the mature glycoprotein gp120 and the transmembrane protein gp41. Both neutralising and non-neutralising patient antibodies are targeted against gp160, making this protein an exciting diagnostic and vaccine target. gp160 is synthesised as a polyprotein and cleaved by the host-resident protease furin (Checkley et al., 2011).

Removal of the intravirion and transmembrane domains allows for production of a soluble secreted version of gp160 termed gp140. The Native Antigen Company now offers untagged HIV-1 glycoprotein gp140 group M subtypes A, B, C, CRF01-AE, group O, and HIV-2 glycoprotein gp140, enabling a new generation of diagnostic assays and structural studies.

Product Name
Order Now!
Human immunodeficiency virus subtype A, gp140 (SOSIP), untagged
REC32083 >>
Human immunodeficiency virus subtype C, gp140 (SOSIP), untagged
REC32084 >>
Human immunodeficiency virus subtype AE, gp140 (SOSIP), untagged
REC32085 >>
Human immunodeficiency virus subtype B, gp140 (SOSIP), untagged
REC32086 >>
Human immunodeficiency virus type 2, gp140 (SOSIP), untagged
REC32076 >>
Human Immunodeficiency virus clade O, gp140 (SOSIP), untagged
REC32082 >>

To learn more about our comprehensive HIV antigen range.

At The Native Antigen Company we also offer a variety of HIV antibodies to further support your R&D

Red Spike Trimer, White Glycans

References

Binley, J.M. et al. (2000) ‘A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and GP41 subunits is an antigenic mimic of the trimeric virion-associated structure’, Journal of Virology, 74(2), pp. 627–643. doi:10.1128/jvi.74.2.627-643.2000.

Checkley, M.A., Luttge, B.G. and Freed, E.O. (2011) ‘HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation’, Journal of Molecular Biology, 410(4), pp. 582–608. doi:10.1016/j.jmb.2011.04.042.

Pugach, P. et al. (2015) ‘A native-like sosip.664 trimer based on an HIV-1 subtype B            env            gene’, Journal of Virology, 89(6), pp. 3380–3395. doi:10.1128/jvi.03473-14.

Get in touch

Would you like to be kept informed of the latest news and innovations from the infectious disease community? Please let us know if you would like us to contact you or not by selecting one of the options below.

8 + 9 =

The Native Antigen Company expands its range of Omicron antigens to include BA.5 variant

New antigens support research into BA.5 variant, currently responsible for over half of global COVID-19 cases Oxford, UK, 02 November 2022: The Native Antigen Company (part of LGC Clinical Diagnostics), one of the world’s leading suppliers of reagents that enables...

The Role of Serology in Tracking COVID-19 Mutations

This article was originally published on Clinical Lab Products. As SARS-CoV-2 began its global proliferation in early 2020, scientists hastened to investigate its biology, develop diagnostic tests, and design candidate vaccines, marking one of the most...

Preparing for Disease Y: A Better Serological Toolbox

This article was originally published on Clinical Lab Manager. It’s been over a year since the World Health Organization (WHO) declared COVID-19 a pandemic. SARS-CoV-2 has since infected 200 million people, resulting in nearly 4 million deaths and substantial economic...

Keeping Up with the New SARS-CoV-2 Variant Nomenclature

If you’ve been struggling to make sense of SARS-CoV-2 variant nomenclature, you’re not alone. Due to the existence of multiple genomic sequence databases, various naming systems are in use for the rapidly growing range of SARS-CoV-2 variants of concern/interest. In a...

Making Sense of the SARS-CoV-2 Spike Mutations

Through much of 2020, SARS-CoV-2 accumulated mutations at a steady, yet unspectacular rate. However, as global cases approached 100 million by the end of the year, multiple variants began to emerge. Exhibiting more considerable genomic changes, some variants have...

D614G: Putting the Mutation in Perspective

Since the emergence of SARS-CoV-2, scientists have speculated about the risks of mutation and what this could mean for therapeutics and vaccines. In this blog, we explore the nature viral mutation, what is known about the D614G mutant of SARS-CoV-2, and introduce our...

The Endemic Coronaviruses and What They Might Tell us About COVID-19

While less-well known than some of their counterparts, the 229E, NL63, OC43, and HKU1 human coronaviruses are a significant cause of respiratory disease worldwide. The evolutionary histories and host associations of the endemic coronaviruses also provide important...

Q&A: An Insight Into COVID-19 Serology

During the course of the current coronavirus pandemic, we have all been aware of the urgent need for nucleic acid testing to identify people currently infected with SARS-CoV-2. The second form of testing needed are serological immunoassays, which can identify past...

A Q&A with David Flavell of Leukaemia Busters

In this blog, we speak with Dr. David Flavell about his scientific career, the legacy of Leukaemia Busters, and the recent impact that COVID-19 has had on his research.Tell me about your scientific background David. I was born in a seaside town called Southport in the...

Avoiding the Immunopathology Pitfalls of a COVID-19 Vaccine

In the second of a three-part series on COVID-19 vaccines, we explore the potential challenges in stimulating safe vaccine responses and outline the role that diagnostics will play in guiding their development.Rogue Responses Antibodies play a crucial role in...

Designing for Differentiation: Why We Need Highly Specific Diagnostics for a COVID-19 Vaccine

Assessment of vaccine-induced immune responses in clinical trials will require highly specific diagnostic assays to ensure safety. This blog was originally published on Clinical Lab Manager.The Vaccine Race Vaccines are the most effective means of preventing...

An Early Look at Vaccines for COVID-19

In the first of a three-part series on the design, immunology and manufacture of COVID-19 vaccines, we take an early look at the major technologies under development and weigh-up the challenges these vaccines will face in reaching late-phase clinical trials.Why We...

Why We Need Antigen and Antibody Tests for COVID-19

RT-PCR is the workhorse of viral diagnosis and has been invaluable in COVID-19 case confirmation and isolation guidance. However, while fast and sensitive, PCR suffers from some inherent drawbacks that limit it to diagnosis during the acute phase of infection. To...

Novel Coronavirus Antigens Now Available

The Native Antigen Company is now offering recombinant S1 and S2 glycoproteins for SARS-CoV-2 (Covid-19) in response to urgent demand. These reagents are suitable for use in basic research and the development of diagnostics and vaccines.These antigens have been...

Coronaviruses: The Next Disease X?

For much of their known history, the coronaviruses were regarded as relatively benign pathogens with little potential to cause human harm. However, the emergence of SARS and MERS in recent decades has brought coronaviruses into the global spotlight. In this blog we...