+44 (0)1865 595230
0 Items

Powassan

Powassan virus is spread to people by the bite of an infected tick. Although considered rare, the number of reported cases of people sick from Powassan virus has increased in recent years. People with severe Powassan virus disease often need to be hospitalized to receive support with breathing and swelling in and around the brain.

 

We have prepared recombinant Powassan NS1 antigen in our mammalian expression system to facilitate development of assays to detect infection with this virus.

Powassan virus background

Powassan virus (POWV) is a positive-sense single-stranded RNA virus that belongs to the genus Flavivirus, a member of the Flaviviridae family of viruses. It is an arthropod-borne virus that is transmitted by infected ticks to small/medium sized mammals, which act as reservoirs for the virus. Different tick species transmit POWV including hard ticks, of the family Ixodidae, and the tick species varies according to the geographical region. POWV can also be transmitted to humans, which are incidental, dead-end, hosts for the virus (Hermance ME, et al).

POWV is classified as a member of the tick-borne encephalitis sero-complex of flaviviruses. Two genotypes, or lineages, of POWV have been identified in Russia and the Western hemisphere. POWV is assigned to lineage I and Deer tick virus (DTV) to lineage II. Serologically the two viruses are indistinguishable but have some phylogenetic differences. Both lineages have been linked to human disease. Cases of POWV infection caused by POWV lineage II (DTV) are reported to be increasing in North America. The virus is transmitted by the tick Ixodes scapularis, which is also the vector for Lymes disease. The expanding distribution of Ixodes scapularis and the high seroprevalence of DTV in small mammals, in endemic regions, suggests that POWV may pose an increasing health threat.
First recognised as a human pathogen in 1958, POWV is the cause of a rare neuroinvasive disease. In humans, the incubation period can vary between 1 – 5 weeks. In many cases, individuals remain asymptomatic or may present with a febrile illness with mild fever, sore throat, headache, drowsiness and disorientation. Some patients develop neurological complications, which include encephalitis, aseptic meningitis and meningoencephalitis. Reports suggest that 10% of POWV cases are fatal and 50% of survivors develop long-term neurological problems, which include acute headaches, muscle wasting and memory problems (CDC).

Currently, there is no antiviral therapy for the treatment of symptomatic cases of POWV, and no licensed prophylactic vaccine to prevent POWV infection. Diagnosis of POWV in humans is achieved using clinical criteria and serological methods to measure Powassan specific IgM levels of infected patients.

References
Hermance ME and Thangamani S. (2017). Powassan Virus: An Emerging Arbovirus of Public Health Concern in North America. Vector Borne Zoonotic Dis. 1; 17(7): 453–462.
Center for Disease Prevention and Control: Powassan virus

Powassan Antigens

Powassan virus NS1 protein 1 (Non-Structural protein 1) has been manufactured in response to the unmet need for highly purified, concentrated protein for use in serological based diagnostic assays. Powassan virus NS1 protein is engineered in human cells using state-of-the-art expression and purification techniques.

Questions?

Check out our FAQ section for answers to the most frequently asked questions about our website and company.

How The Native Antigen Company responds to the WHO list of priority infectious diseases

In 2015, a broad group of public health and science experts gathered in Geneva to discuss emerging infectious diseases that are likely to cause future severe epidemics and public health emergencies. Organised by the World Health Organization (WHO), their aim was to...

Native Antigen release a panel of serotype specific monoclonal antibodies

  There are four distinct serotypes of Dengue Virus circulating around the world, causing Dengue fever infection which is the most important worldwide arboviral disease. There are nearly 400 million cases of Dengue annually, and around 25% present with so called...

A silver-lining from Zika virus?

Zika virus (ZIKV) is an enveloped single stranded RNA virus. It is a member of the Flavivirus genus of the family Flaviviridae, which is transmitted to humans primarily through the bite of the Aedes aegypti mosquito. In 2015, a major outbreak of Zika virus was...

Congenital CMV – a problem ignored?

Congenital CMV infection – a serious problem that receives little attention Cytomegalovirus (CMV) is a human specific double stranded DNA virus, belonging to the Herpesviridae family. CMV is ubiquitous and CMV infection is globally widespread. The virus can be...

New Nipah Virus antigens now available from The Native Antigen Company

Infection with Nipah Virus (NiV) was first recognised in Malaysia 1998/1999, where a major outbreak occurred in pigs and humans. NiV infection is now endemic in South Asia and several outbreaks of NiV infection have been reported in India and Bangladesh. Currently an...

Get in Touch With Us

The Native Antigen Company sometimes likes to send exclusive information and offers to our customers, please let us know if you are happy to receive these

15 + 11 =

Customer Feedback